Author(s): Döbert N, Britten M, Assmus B, Berner U, Menzel C, et al.
Clinical outcome after myocardial infarction depends on the extent of irreversibly damaged myocardium. Implantation of bone marrow-/circulating blood-derived progenitor cells has been shown to improve contractile cardiac function after myocardial infarction in both experimental and initial clinical studies. In the present study, first observations of the effect of local intracoronary progenitor cell infusion on the regeneration of infarcted cardiac tissue after acute myocardial infarction was evaluated by means of 18F-fluorodeoxyglucose positron emission tomography (PET) and 201Tl single-photon emission computed tomography (SPECT). Twenty-six patients underwent intracoronary infusion of bone marrow-derived (BMCs) (15 patients) or circulating blood-derived endothelial progenitor cells (EPCs) (11 patients) 4+/-2 days after acute myocardial infarction. Based on a left ventricular segmentation model (17 segments), mean signal intensities as a parameter of viability and perfusion in the infarct zone and non-infarct areas were calculated quantitatively by PET and SPECT at baseline and at 4 months of follow-up. Transplantation of progenitor cells was associated with a significant increase in the mean signal intensity (MSI) in the infarct zone from 54.5% (25th and 75th percentiles: 47.7%, 60.0%) to 58.0% (52.7%, 66.7%) on PET (P=0.013) and from 58.0% (49.5%, 63.0%) to 61.5% (52.5%, 70.2%) on SPECT (P=0.005). Global left ventricular ejection fraction (LVEF) increased from 53.5% (42.6%, 60.0%) to 58.0% (53.0%, 65.8%) (P<0.001). In the five patients without an increase in MSI on PET, LVEF changed from 60.0% (50.0%, 64.0%) to 72.0% (64.0%, 75.5%) at follow-up. PET and SPECT did not show any significant changes in MSI in the non-infarct areas [from 73% (68.5%, 76.2%) to 73% (69.7%, 78.0%) for PET and from 72.0% (66.5%, 77.6%) to 73.0% (67.5%, 78.2%) for SPECT]. There were no significant differences in myocardial viability and perfusion between BMC and EPC infusion. These preliminary results show that coronary stenting and transplantation of progenitor cells result in a significant increase in myocardial viability and perfusion. Therapeutic effects can be reliably measured by PET and SPECT.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/15064873
Author(s): Davenport R, Dennis M
Author(s): Sudlow CL, Warlow CP
Author(s): Fagan SC, Morgenstern LB, Petitta A, Ward RE, Tilley BC, et al.
Author(s): Hess DC, Wang S, Hamilton W, Lee S, Pardue C, et al.
Author(s): Wang S, Gross H, Lee SB, Pardue C, Waller J, et al.
Author(s): Borlongan CV, Fournier C, Stahl CE, Yu G, Xu L, et al.
Author(s): Wang X, Rosell A, Lo EH
Author(s): Switzer JA, Hall C, Gross H, Waller J, Nichols FT, et al.
Author(s): Leira EC, Hess DC, Torner JC, Adams HP Jr
Author(s): Henninger N, Chowdhury N, Fisher M, Moonis M
Author(s): Wu O, Langhorne P
Author(s): Matsukawa N, Yasuhara T, Hara K, Xu L, Maki M, et al.
Author(s): Hill MD, Moy CS, Palesch YY, Martin R, Dillon CR, et al.
Author(s): Toda H, Takahashi J, Iwakami N, Kimura T, Hoki S, et al.
Author(s): Ferrari A, Ehler E, Nitsch RM, Götz J
Author(s): Borlongan CV, Tajima Y, Trojanowski JQ, Lee VMY, Sanberg PR
Author(s): Veizovic T, Beech JS, Stroemer RP, Watson WP, Hodges H
Author(s): Modo M, Stroemer RP, Tang E, Veizovic T, Sowniski P, et al.
Author(s): Englund U, Bjorklund A, Wictorin K, Lindvall O, Kokaia M
Author(s): Kopen GC, Prockop DJ, Phinney DG
Author(s): Chen J, Li Y, Chopp M
Author(s): Li Y, Chopp M, Chen J, Wang L, Gautam SC, et al.
Author(s): Woodbury D, Schwarz EJ, Prockop DJ, Black IB
Author(s): Muñoz-Elias G, Marcus AJ, Coyne TM, Woodbury D, Black IB
Author(s): Borlongan CV, Hadman M, Sanberg CD, Sanberg PR
Author(s): Eglitis MA, Mezey E
Author(s): Li Y, Chen J, Wang L, Lu M, Chopp M
Author(s): Chen J, Sanberg PR, Li Y, Wang L, Lu M, et al.
Author(s): Hess DC, Hill WD, Martin-Studdard A, Carroll J, Brailer J, et al.
Author(s): Willing AE, Lixian J, Milliken M, Poulos S, Zigova T, et al.
Author(s): Chen J, Zhang ZG, Li Y, Wang L, Xu YX, et al.
Author(s): Riess P, Zhang C, Saatman KE, Laurer HL, Longhi LG, et al.
Author(s): Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, et al.
Author(s): Peled A, Kollet O, Ponomaryov T, Petit I, Franitza S, et al.
Author(s): Yamaguchi J, Kusano KF, Masuo O, Kawamoto A, Silver M, et al.
Author(s): Reyes M, Dudek A, Jahagirdar B, Koodie L, Marker PH, et al.
Author(s): Rajantie I, Ilmonen M, Alminaite A, Ozerdem U, Alitalo K, et al.
Author(s): Mahmood A, Lu D, Chopp M
Author(s): Suárez-Monteagudo C, Hernández-Ramírez P, Alvarez-González L, García-Maeso I, de la Cuétara-Bernal K, et al.
Author(s): Borlongan CV
Author(s): Feuerstein GZ, Zaleska MM, Krams M, Wang X, Day M, et al.
Author(s): Keene CD, Ortiz-Gonzalez XR, Jiang YH, Largaespada DA, Verfaillie CM, et al.
Author(s): Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, et al.
Author(s): Jorgensen C, Djouad F, Apparailly F, Noël D
Author(s): Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringdén O
Author(s): Aggarwal S, Pittenger MF
Author(s): Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC
Author(s): Le Blanc K, Rasmusson I, Sundberg B, Götherström C, Hassan M, et al.
Author(s): Reyes M, Verfaillie CM
Author(s): Ayata C, Ropper AH
Author(s): Brouns R, De Deyn PP
Author(s): Aoki T, Sumii T, Mori T, Wang XY, Lo EH
Author(s): Subramaniam S, Hill MD
Author(s): Chang CF, Lin SZ, Chiang YH, Morales M, Chou J, et al.
Author(s): Castillo J, Alvarez-Sabín J, Martínez-Vila E, Montaner J, Sobrino T, et al.
Author(s): Vila N, Castillo J, Dávalos A, Chamorro A
Author(s): Castillo J, Leira R
Author(s): Doyle KP, Simon RP, Stenzel-Poore MP
Author(s): Wang GJ, Deng HY, Maier CM, Sun GH, Yenari MA
Author(s): Tang Y, Xu H, Du X, Lit L, Walker W, et al.
Author(s): Carmeliet P
Author(s): Masuda H, Asahara T
Author(s): Shi Q, Rafii S, Wu MH, Wijelath ES, Yu C, et al.
Author(s): Bompais H, Chagraoui J, Canron X, Crisan M, Liu XH, et al.
Author(s): Pirro M, Schillaci G, Menecali C, Bagaglia F, Paltriccia R, et al.
Author(s): Umemura T, Soga J, Hidaka T, Takemoto H, Nakamura S, et al.
Author(s): Del Papa N, Quirici N, Soligo D, Scavullo C, Cortiana M, et al.
Author(s): Kuwana M, Okazaki Y, Yasuoka H, Kawakami Y, Ikeda Y
Author(s): Heiss C, Keymel S, Niesler U, Ziemann J, Kelm M, et al.
Author(s): Kondo T, Hayashi M, Takeshita K, Numaguchi Y, Kobayashi K, et al.
Author(s): Michaud SE, Dussault S, Haddad P, Groleau J, Rivard A
Author(s): Botta R, Gao E, Stassi G, Bonci D, Pelosi E, et al.
Author(s): Kawamoto A, Gwon HC, Iwaguro H, Yamaguchi JI, Uchida S, et al.
Author(s): Madeddu P, Emanueli C, Pelosi E, Salis MB, Cerio AM, et al.
Author(s): Rouhl RP, van Oostenbrugge RJ, Damoiseaux J, Tervaert JW, Lodder J
Author(s): Erbs S, Linke A, Adams V, Lenk K, Thiele H, et al.
Author(s): Li ZQ, Zhang M, Jing YZ, Zhang WW, Liu Y, et al.
Author(s): Meluzín J, Janousek S, Mayer J, Groch L, Hornácek I, et al.
Author(s): Meluzín J, Mayer J, Groch L, Janousek S, Hornácek I, et al.
Author(s): Mocini D, Staibano M, Mele L, Giannantoni P, Menichella G, et al.
Author(s): Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, et al.
Author(s): Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, et al.
Author(s): Strauer BE, Brehm M, Zeus T, Bartsch T, Schannwell C, et al.
Author(s): Strauer BE, Brehm M, Zeus T, Köstering M, Hernandez A, et al.
Author(s): Numaguchi Y, Sone T, Okumura K, Ishii M, Morita Y, et al.
Author(s): Lev EI, Kleiman NS, Birnbaum Y, Harris D, Korbling M, et al.
Author(s): Hristov M, Heussen N, Schober A, Weber C
Author(s): Dimmeler S, Zeiher AM, Schneider MD
Author(s): Higashi Y, Kimura M, Hara K, Noma K, Jitsuiki D, et al.
Author(s): Tateishi-Yuyama E, Matsubara H, Murohara T, Ikeda U, Shintani S, et al.
Author(s): Taguchi A, Matsuyama T, Moriwaki H, Hayashi T, Hayashida K, et al.
Author(s): Ghani U, Shuaib A, Salam A, Nasir A, Shuaib U, et al.
