Epidemiology and risk factors for early onset sepsis among very-low-birthweight infants

Author(s): Klinger G, Levy I, Sirota L, Boyko V, Reichman B, et al.

Abstract

Objective: The purpose of this study was to determine the incidence, causative pathogens, and risk factors for early onset sepsis (EOS) among very-low-birthweight (VLBW) infants.

Study design: This was a population based observational study. Data were prospectively collected by the Israel Neonatal Network between 1995 and 2005. Multivariable analyses identified independent risk factors for EOS.

Results: EOS developed in 383 of 15,839 infants (2.42%). Fifty-five percent of pathogens isolated were gram-negative bacteria. Lack of prenatal care (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.32-2.86), delivery room resuscitation (OR, 2.49; 95% CI, 1.91-3.24), membrane rupture > 24 hours without amnionitis (OR, 2.10; 95% CI, 1.53-2.88), amnionitis with membrane rupture < 24 hours (OR, 4.28; 95% CI, 2.97-6.16), and amnionitis with membrane rupture >or= 24 hours (OR, 8.15; 95% CI, 5.98-11.10) were associated with EOS, but not antenatal steroids or gestational age.

Conclusion: EOS was caused mainly by gram-negative bacteria. Prolonged rupture of membranes and amnionitis have an additive effect on EOS with an above 8-fold excess risk when both were present.

Similar Articles

Validation of caregiver interviews to diagnose common causes of severe neonatal illness

Author(s): Kalter HD, Hossain M, Burnham G, Khan NZ, Saha SK, et al.

The World Health Report 1995--bridging the gaps

Author(s): [No authors listed]

Bacteraemia in patients presenting with fever

Author(s): Petit PL, Haarlem JV, Poelman M, Haverkamp MC, Wamola IA

Neonatal deaths in Calabar, Nigeria

Author(s): Asindi AA, Ekanem AD

Mortality pattern among Nigerian children in the 1980s

Author(s): Asindi AA, Ibia EO, Udo JJ

Septicaemia in high risk neonates at a teaching hospital in Ile-Ife, Nigeria

Author(s): Adejuyigbe EA, Adeodu OO, Ako-Nai KA, Taiwo O, Owa JA

Kernicterus: still a concern

Author(s): Juretschke LJ

Rehospitalisation after birth hospitalisation: patterns among infants of all gestations

Author(s): Escobar GJ, Greene JD, Hulac P, Kincannon E, Bischoff K, et al.

Neonatal morbidity and mortality in Nigeria

Author(s): Owa JA, Osinaike AI

Risk factors for ne onatal mortality in a regional tertiary hospital in Nigeria

Author(s): Ezechukwu CC, Ugochukwu EF, Egbuonu I, Chukwuka JO

Pattern of admissions to neonatal unit

Author(s): Parkash J, Das N

[Treatment of neonatal jaundice]

Author(s): Hansen TW

Central Nervous System Infections

Author(s): Prober CG

Salmonella meningitis in infancy

Author(s): SMITH ES

Malaria in the first 6 months of life in urban African infants with anemia

Author(s): Afolabi BM, Salako LA, Mafe AG, Ovwigho UB, Rabiu KA, et al.

Rev

Author(s): Whaley LF, Wong DL

Septicaemia among neonates with tetanus

Author(s): Antia-Obong OE, Ekanem EE, Udo JJ, Utsalo SJ

Bacterial isolates from blood cultures of children with suspected septicaemia in Calabar, Nigeria

Author(s): Meremikwu MM, Nwachukwu CE, Asuquo AE, Okebe JU, Utsalo SJ

Half a decade of neonatal sepsis, Riyadh, Saudi Arabia

Author(s): Haque KN, Chagia AH, Shaheed MM

A graphical decision-theoretic model for neonatal jaundice

Author(s): Gómez M, Bielza C, Fernández del Pozo JA, Ríos-Insua S

Neonatal Tetanus in Port Harcourt

Author(s): Orumabo RS, Mbagbaw LT

Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension

Author(s): Lakshminrusimha S, Swartz DD, Gugino SF, Ma CX, Wynn KA, et al.

Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen

Author(s): Vento M, Asensi M, Sastre J, Lloret A, García-Sala F, et al.

Neonatal salmonella meningitis complicated by cerebral abscesses

Author(s): West SE, Goodkin R, Kaplan AM