Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen

Author(s): Vento M, Asensi M, Sastre J, Lloret A, García-Sala F, et al.

Abstract

Objective: To test the hypothesis that resuscitation of asphyxiated infants with pure oxygen causes hyperoxemia and oxidative stress.Study design Asphyxiated term newborn infants (n = 106) were randomly resuscitated with room air (RAR = 51) or 100% oxygen (OxR = 55). The Apgar score, time of the first cry, and establishment of a sustained pattern of respiration were recorded. Assays performed included: blood gases; reduced glutathione (GSH) and oxidized glutathione (GSSG) in whole blood; glutathione-related enzyme activities; and superoxide dismutase activity (SOD) in erythrocytes.

Results: The RAR group needed less time of ventilation for resuscitation (5.3 +/- 1.5 vs 6.8 +/- 1.2 min; P <.05). Pure oxygen caused hyperoxemia (PO(2), 126.3 +/- 21.8 mm Hg) that did not occur with the use of room air (PO(2), 72.2 +/- 6.8 mm Hg). GSH was decreased and GSSG, the glutathione cycle enzymes, and SOD activities were increased in both asphyxiated groups. However, the 100% oxygen-resuscitated group showed significantly greater alterations that correlated positively with hyperoxemia.

Conclusions: Asphyxia causes oxidative stress in the perinatal period, and resuscitation with 100% oxygen causes hyperoxemia and increased oxidative stress. Because there are no advantages to resuscitation with 100% oxygen, room air may be preferred under certain circumstances for the resuscitation of asphyxiated neonates.

Similar Articles

Validation of caregiver interviews to diagnose common causes of severe neonatal illness

Author(s): Kalter HD, Hossain M, Burnham G, Khan NZ, Saha SK, et al.

The World Health Report 1995--bridging the gaps

Author(s): [No authors listed]

Bacteraemia in patients presenting with fever

Author(s): Petit PL, Haarlem JV, Poelman M, Haverkamp MC, Wamola IA

Neonatal deaths in Calabar, Nigeria

Author(s): Asindi AA, Ekanem AD

Mortality pattern among Nigerian children in the 1980s

Author(s): Asindi AA, Ibia EO, Udo JJ

Septicaemia in high risk neonates at a teaching hospital in Ile-Ife, Nigeria

Author(s): Adejuyigbe EA, Adeodu OO, Ako-Nai KA, Taiwo O, Owa JA

Kernicterus: still a concern

Author(s): Juretschke LJ

Rehospitalisation after birth hospitalisation: patterns among infants of all gestations

Author(s): Escobar GJ, Greene JD, Hulac P, Kincannon E, Bischoff K, et al.

Neonatal morbidity and mortality in Nigeria

Author(s): Owa JA, Osinaike AI

Risk factors for ne onatal mortality in a regional tertiary hospital in Nigeria

Author(s): Ezechukwu CC, Ugochukwu EF, Egbuonu I, Chukwuka JO

Pattern of admissions to neonatal unit

Author(s): Parkash J, Das N

[Treatment of neonatal jaundice]

Author(s): Hansen TW

Central Nervous System Infections

Author(s): Prober CG

Salmonella meningitis in infancy

Author(s): SMITH ES

Malaria in the first 6 months of life in urban African infants with anemia

Author(s): Afolabi BM, Salako LA, Mafe AG, Ovwigho UB, Rabiu KA, et al.

Rev

Author(s): Whaley LF, Wong DL

Epidemiology and risk factors for early onset sepsis among very-low-birthweight infants

Author(s): Klinger G, Levy I, Sirota L, Boyko V, Reichman B, et al.

Septicaemia among neonates with tetanus

Author(s): Antia-Obong OE, Ekanem EE, Udo JJ, Utsalo SJ

Bacterial isolates from blood cultures of children with suspected septicaemia in Calabar, Nigeria

Author(s): Meremikwu MM, Nwachukwu CE, Asuquo AE, Okebe JU, Utsalo SJ

Half a decade of neonatal sepsis, Riyadh, Saudi Arabia

Author(s): Haque KN, Chagia AH, Shaheed MM

A graphical decision-theoretic model for neonatal jaundice

Author(s): Gómez M, Bielza C, Fernández del Pozo JA, Ríos-Insua S

Neonatal Tetanus in Port Harcourt

Author(s): Orumabo RS, Mbagbaw LT

Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension

Author(s): Lakshminrusimha S, Swartz DD, Gugino SF, Ma CX, Wynn KA, et al.

Neonatal salmonella meningitis complicated by cerebral abscesses

Author(s): West SE, Goodkin R, Kaplan AM