Septicaemia in high risk neonates at a teaching hospital in Ile-Ife, Nigeria

Author(s): Adejuyigbe EA, Adeodu OO, Ako-Nai KA, Taiwo O, Owa JA


Objectives: To determine the incidence, predisposing factors, clinical features, bacteriological pattern and antibiotic sensitivity in septicaemia in high-risk newborns.

Design: A prospective study.

Setting: Neonatal unit, Ife State Hospital, a unit of the Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile-Ife, Nigeria.

Subjects: All newborns admitted with clinical features and/or risk factors suggestive of neonatal septicaemia from February 1994 to March 1995.

Main outcome measures: Culture results and mortality rates.

Results: The incidence of neonatal septicaemia among new born was 22.9 per 1000 livebirths. The predisposing perinatal factors were low socio-economic status, lack of antenatal care, maternal peripartum pyrexia and congenital malformations. Gram-positive bacteria were found to be the most prevalent causative organisms (59.4%). Staphylococcus aureus (36.2%), Pseudomonas aeruginosa (18.8%) and Coagulase negative Staphylococcus (15.9%) were the commonest causes of septicaemia. Meningitis and UTI were associated diagnoses in 16.7% and 18.2% of the septicaemic babies, respectively. The bacterial isolates showed a high degree of in-vitro antimicrobial resistance. However, all the isolates were sensitive to ofloxacin. Amongst the commonly used antibiotics, gentamicin had the lowest resistance. The overall mortality rate was 33.3%.

Conclusion: Improvement in the socio-economic status of the populace and availability of affordable antenatal care would reduce the incidence of neonatal septicaemia in Nigeria. Continuous surveillance in every unit, as well as close attention to preventive strategies would be necessary to reduce morbidity and mortality from neonatal septicaemia. We recommend the inclusion of gentamicin in the initial treatment of septicaemia in the neonatal unit of OAUTHC, Ile-Ife, Nigeria.

Similar Articles

Validation of caregiver interviews to diagnose common causes of severe neonatal illness

Author(s): Kalter HD, Hossain M, Burnham G, Khan NZ, Saha SK, et al.

The World Health Report 1995--bridging the gaps

Author(s): [No authors listed]

Bacteraemia in patients presenting with fever

Author(s): Petit PL, Haarlem JV, Poelman M, Haverkamp MC, Wamola IA

Neonatal deaths in Calabar, Nigeria

Author(s): Asindi AA, Ekanem AD

Mortality pattern among Nigerian children in the 1980s

Author(s): Asindi AA, Ibia EO, Udo JJ

Kernicterus: still a concern

Author(s): Juretschke LJ

Rehospitalisation after birth hospitalisation: patterns among infants of all gestations

Author(s): Escobar GJ, Greene JD, Hulac P, Kincannon E, Bischoff K, et al.

Neonatal morbidity and mortality in Nigeria

Author(s): Owa JA, Osinaike AI

Risk factors for ne onatal mortality in a regional tertiary hospital in Nigeria

Author(s): Ezechukwu CC, Ugochukwu EF, Egbuonu I, Chukwuka JO

Pattern of admissions to neonatal unit

Author(s): Parkash J, Das N

[Treatment of neonatal jaundice]

Author(s): Hansen TW

Central Nervous System Infections

Author(s): Prober CG

Salmonella meningitis in infancy

Author(s): SMITH ES

Malaria in the first 6 months of life in urban African infants with anemia

Author(s): Afolabi BM, Salako LA, Mafe AG, Ovwigho UB, Rabiu KA, et al.


Author(s): Whaley LF, Wong DL

Epidemiology and risk factors for early onset sepsis among very-low-birthweight infants

Author(s): Klinger G, Levy I, Sirota L, Boyko V, Reichman B, et al.

Septicaemia among neonates with tetanus

Author(s): Antia-Obong OE, Ekanem EE, Udo JJ, Utsalo SJ

Bacterial isolates from blood cultures of children with suspected septicaemia in Calabar, Nigeria

Author(s): Meremikwu MM, Nwachukwu CE, Asuquo AE, Okebe JU, Utsalo SJ

Half a decade of neonatal sepsis, Riyadh, Saudi Arabia

Author(s): Haque KN, Chagia AH, Shaheed MM

A graphical decision-theoretic model for neonatal jaundice

Author(s): Gómez M, Bielza C, Fernández del Pozo JA, Ríos-Insua S

Neonatal Tetanus in Port Harcourt

Author(s): Orumabo RS, Mbagbaw LT

Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension

Author(s): Lakshminrusimha S, Swartz DD, Gugino SF, Ma CX, Wynn KA, et al.

Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen

Author(s): Vento M, Asensi M, Sastre J, Lloret A, García-Sala F, et al.

Neonatal salmonella meningitis complicated by cerebral abscesses

Author(s): West SE, Goodkin R, Kaplan AM