Mortality and intestinal failure in surgical necrotizing enterocolitis

Author(s): Kelleher J, Mallick H, Soltau TD, Harmon CM, Dimmitt RA


Background/purpose:To examine whether as initial surgical intervention for necrotizing enterocolitis, primary peritoneal drainage as compared to primary laparotomy is associated with increased mortality or intestinal failure.

Methods:Retrospective observational study of 240 infants with surgical necrotizing enterocolitis.

Results:There was no difference concerning the composite outcome of mortality before discharge or survival with intestinal failure after adjusting for known covariates (Odds Ratio 1.73, 95% CI 0.88, 3.40). More surviving infants in the peritoneal drainage with subsequent salvage or secondary laparotomy had intestinal failure compared to those who received a peritoneal drain without subsequent laparotomy and survived (12% vs. 14% vs. 1%, p=0.015).

Conclusions:There is no difference between peritoneal drainage and laparotomy in infants with surgical necrotizing enterocolitis concerning the combined outcome of mortality or survival with intestinal failure. There is increased intestinal failure in surviving infants treated with peritoneal drain with either subsequent salvage or secondary laparotomy compared to peritoneal drainage alone.

Similar Articles

Neonatal necrotizing enterocolitis: Therapeutic decisions based upon clinical staging

Author(s): Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, et al.

The early use of minimal enteral nutrition in extremely low birth weight newborns

Author(s): Mosqueda E, Sapiegiene L, Glynn L, Wilson-Costello D, Weiss M

Necrotizing enterocolitis in 20,822 infants: analysis of medical and surgical treatments

Author(s): Abdullah F, Zhang Y, Camp M, Mukherjee D, Gabre-Kidan A, et al.

Survival and morbidity of infants with necrotizing enterocolitis treated with surgery

Author(s): García H, Franco-Gutiérrez M, Gutiérrez-Hernández JI

Short-term outcomes for preterm infants with surgical necrotizing enterocolitis

Author(s): Murthy K, Yanowitz TD, DiGeronimo R, Dykes FD, Zaniletti I, et al.