Author(s): Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, et al.
A method of clinical staging for infants with necrotizing enterocolitis (NEC) is proposed. On the basis of assigned stage at the time of diagnosis, 48 infants were treated with graded intervention. For Stage I infants, vigorous diagnostic and supportive measures are appropriate. Stage II infants are treated medically, including parenteral and gavage aminoglycoside antibiotic, and Stage III patients require operation. All Stage I patients survived, and 32 of 38 Stage II and III patients (85%) survived the acute episode of NEC. Bacteriologic evaluation of the gastrointestinal microflora in these neonates has revealed a wide range of enteric organisms including anaerobes. Enteric organisms were cultured from the blood of four infants dying of NEC. Sequential cultures of enteric organisms reveal an alteration of flora during gavage antibiotic therapy. These studies support the use of combination antimicrobial therapy in the treatment of infants with NEC.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/413500
Author(s): Obladen M
Author(s): Horton KK
Author(s): Neu J
Author(s): Salhab WA, Perlman JM, Silver L, Broyles RS
Author(s): Watkins DJ, Besner GE
Author(s): Ng PC
Author(s): De Plaen IG
Author(s): Kasivajjula H, Maheshwari A
Author(s): Lau CS, Chamberlain RS
Author(s): Fisher JG, Jones BA, Gutierrez IM, Hull MA, Kang KH, et al.
Author(s): Walsh MC, Kliegman RM
Author(s): PorcelliJr PJ, Sisk PM
Author(s): Thureen PJ, Melara D, Fennessey PV, Hay WW Jr
Author(s): Kalhan SC, Kilic I
Author(s): Sinclair JC, Bottino M, Cowett RM
Author(s): Mosqueda E, Sapiegiene L, Glynn L, Wilson-Costello D, Weiss M
Author(s): Abdullah F, Zhang Y, Camp M, Mukherjee D, Gabre-Kidan A, et al.
Author(s): García H, Franco-Gutiérrez M, Gutiérrez-Hernández JI
Author(s): Murthy K, Yanowitz TD, DiGeronimo R, Dykes FD, Zaniletti I, et al.
Author(s): Hull MA, Fisher JG, Gutierrez IM, Jones BA, Kang KH, et al.
Author(s): Kelleher J, Mallick H, Soltau TD, Harmon CM, Dimmitt RA
Author(s): Nah SA, Tan HL, Tamba RP, Aziz DA, Azzam N
Author(s): Smith J, Thyoka M
Author(s): Wang XM, Zhu YP, Wang L