Acetogenins from Annonaceae, inhibitors of mitochondrial complex I

Author(s): Zafra-Polo MC, González MC, Estornell E, Sahpaz S, Cortes D

Abstract

One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain).

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