Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients

Author(s): Arakawa H, Jinnin M, Muchemwa FC, Makino T, Kajihara I, et al.

Abstract

In this study, we determined the adiponectin expression in the serum and lesional skin of patients with scleroderma (SSc). Serum adiponectin concentrations were measured in 32 patients with SSc, 10 patients with SLE, 12 patients with dermatomyositis patients and 13 healthy subjects with specific enzyme-linked immunosorbent assays. Adiponectin mRNA was determined in skin tissues of five patients with diffuse cutaneous SSc (dcSSc), seven patients with limited cutaneous SSc (lcSSc) and seven healthy subjects with real-time polymerase chain reaction. There was a significant reduction in serum adiponectin levels in patients with dcSSc. SSc patients with decreased serum adiponectin levels had higher total skin thickness score and higher incidence of pulmonary fibrosis. Adiponectin mRNA levels in skin tissues from patients with dcSSc were also reduced. Serum adiponectin levels may be a useful biomarker for fibrotic condition in patients with SSc. Clarifying the role of adiponectin in collagen diseases may lead to further understanding of the pathogenesis and new therapeutic approach.

Similar Articles

Antioxidant and anti-inflammatory activities of quercetin 7-O-β-D-glucopyranoside from the leaves of Braseniaschreberi

Author(s): Legault J, Perron T, Mshvildadze V, Girard-Lalancette K, Perron S, et al.

Cyclohexene, diketopiperazine, lactone and phenol derivatives from the sea fan-derived fungi Nigrospora sp

Author(s): Rukachaisirikul T, Khamthong N, Sukpondma Y, Phongpaichit S, Hutadilok-Towatana N, et al.

Hypolaetin 7-glucoside from Juniperusmacropoda

Author(s): Siddiqui SA, Sen AB

Flavonol glycosides gallates from Tellimagrandiflora

Author(s): Collins FW, Bohm BA, Wilkins CK

Constituents of the leaves of WoodfordiafruticosaKurz

Author(s): Kadota S, Takamori Y, Khin N, Kikuchi T, Tanaka K, et al.

Facile synthesis of flavonoid 7-O-glycosides

Author(s): Li M, Han X, Yu B

Flavonoid galloylglucosides from the pods of Acaciafarnesiana

Author(s): Barakat HH, Souleman AM, Hussein SAM, Ibrahiem OA, Nawwar MAM

Facile discrimination of aldose enantiomers by reversed-phase HPLC

Author(s): Tanaka T, Nakashima T, Ueda T, Tomii K, Kouno I

Comparative phytochemical and morphological analyses of three Italian Primula species

Author(s): Fico G, Rodondi G, Flamini G, Passarella D, Tomé F

Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion

Author(s): Kunimasa K, Kuranuki S, Matsuura N, Iwasaki N, Ikeda M, et al.

Clinical status and cardiovascular risk profile of adults with a history of juvenile dermatomyositis

Author(s): Eimer MJ, Brickman WJ, Seshadri R, Ramsey-Goldman R, McPherson DD, et al.

Biochemical markers of psoriasis as a metabolic disease

Author(s): Gerkowicz A, Pietrzak A, Szepietowski JC, Radej S, Chodorowska G

Adiponectin expression in subcutaneous adipose tissue is reduced in women with cellulite

Author(s): Emanuele E, Minoretti P, Altabas K, Gaeta E, Altabas V

Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes

Author(s): Statnick MA, Beavers LS, Conner LJ, Corominola H, Johnson D, et al.