Amide derivatives of p-isobutyl-phenyl-propionic acids and related pharmaceutical compositions

Author(s): Reiner A

Abstract

The amide derivatives of p-isobutyl-phenyl-propionic acid, having general formula ##STR1## wherein X is the radical of a substituted amine, of the group comprising lysine, metatrifluorotoluidine, glutamic acid and aspartic acid, show a good anti-inflammatory activity, accompanied by favourable side properties. For the preparation of the compounds of the invention, the p-isobutyl-phenyl-propionic acid is chlorinated, and the chlorinated derivative is reacted with the proper substituted amine.

Similar Articles

A novel colon-specific steroid prodrug enhances sodium chloride absorption in rat colitis

Author(s): Fedorak RN, Cui N, Friend DR, Madsen KL, Empey LR

Novel prodrugs of meropenem with two lipophilic promoieties: Synthesis and pharmacokinetics

Author(s): Tanaka S, Matsui H, Kasai M, Kunishiro K, Kakeya N, et al.

Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets

Author(s): Friedrich RB, Ravanello A, Cichota LC, Rolim CMB, Beck RCR