Author(s): Trush MA, Kensler TW
Substantial experimental evidence exists which implicates both oxygen- and organic-free radical intermediates in the multiple stages of chemical carcinogenesis. This overview summarizes some of the biochemical and molecular interactions which could result from a state of oxidative stress following the generation of free radical intermediates from chemical carcinogens in target cells. Evidence for a relationship between carcinogenesis and inflammation as a mediator of oxidative stress is also discussed. Understanding the interactions of radical intermediates with target biomolecules should lead to the development of relevant biomarkers of these interactions as well as rational chemoprotective strategies with antioxidants or other radical detoxifiers for the prevention of neoplasia.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/1864525
Author(s): Adomi OP, Umukoro GE
Author(s): Ebiloma GU, Omale J, Aminu RO
Author(s): Adesida GA, Adesogan EK
Author(s): Prohp TP, Onoagbe IO
Author(s): Lorke D
Author(s): Gonzalez-Avila MM, Arriaga-Alba M, Garza de la, Carmen HP, del Dominguez-Ortiz M, et al
Author(s): Singh BN, Singh BR, Singh RL, Prakash D, Dhakarey R, et al.
Author(s): Vuillaume M
Author(s): Witz G
Author(s): Jang D, Murrell GA
Author(s): Passos DC, Ferreira HD, Vieira ILFB, Nunes WB, Felício LP
Author(s): Wan-Ibrahim WI, Sidik KS, Kuppusam UR
Author(s): Roy M, Sinha D, Mukherjee S, Paul S, Bhattacharya RK
Author(s): Serpeloni JM, Bisarro dos Reis M, Rodrigues J, Campaner dos Santos L, Vilegas W, et al.
Author(s): Burrows CJ, Muller JG
Author(s): Lee JC, Kim HR, Kim J, Jang YS
Author(s): Halliwell B, Gutteridge JM