Author(s): Xu Z, Zhang Y, Fu H, Zhong H, Hong K, et al.
Two new quinazolinones alkaloids, R(+)-2-(heptan-3-yl)quinazolin-4(3H)-one (1) and (2R,3'R)+(2S,3'R)-2-(heptan-3-yl)-2,3-dihydroquinazolin-4(1H)-one (2) (a pair of epimers), as well as seven known analogues, 2-methylquinazolin-4(3H)-one (3), 2-benzylquinazolin-4(3H)-one (4), cyclo-(Pro-Ile), cyclo-(Pro-Leu), cyclo-(Pro-Val), cyclo-(Pro-Phe), and cyclo-(Tyr-Pro) were isolated from the n-butyl alcohol extract of the marine-derived bacterium Bacillus cereus 041381. The new compounds were identified by spectroscopic analysis and chemical synthesis. Four optical isomers 5-8 were also synthesized. Compounds 1-8 all showed moderate antifungal activity against Candida albicans with MIC values of 1.3-15.6 μM. Compound 5 exhibits the most powerful antifungal activity, which may reveal that S-configuration and 2,3-double bond were necessary for antifungal activity, and the racemization at C-2 and C-3' reduced the antifungal activity.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/21612927
Author(s): Moghimi A, Khanmiri RH, Omrani I, Shaabani A
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Author(s): Lu L, Zhang MM, Jiang H, Wang XS
Author(s): El-Azab AS, Eltahir KE
Author(s): Wang Z, Wang M, Yao X, Li Y, Tan J, et al.
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Author(s): Yadav AK, Dhakad P, Sharma GR
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