Anti-inflammatory function of arctiin by inhibition COX-2 expression via NF-kB pathways

Author(s): Lee S, Shin S, Kim H, Han S, Kim K, et al.

Abstract

Background

Arctiin, isolated from Forsythia suspensa has been reported to have anti-inflammatory, anti-oxidant, antibacterial, and antiviral effects in vitro. However, there has been a lack of studies regarding its effects on immunological activity. The aim of this study is to investigate the anti-inflammatory potential and possible mechanisms of arctiin in LPS-induced macrophages.

Methods

We investigated the mRNA and protein levels of proinflammatory cytokines through RT-PCR and western blot analysis, followed by a FACS analysis for surface molecule changes.

Similar Articles

Mannan from Aloe saponaria inhibits tumoral cell activation and proliferation

Author(s): Sampedro MC, Artola RL, Murature M, Murature D

Modified Aloe barbadensis polysaccharide with immunomodulatory activity

Author(s): Qui Z, Jones K, Wylie M, Jia Q, Orndorff S

Pharmacological studies on a plant lectin, Aloctin A

Author(s): Imanishi K, Ishiguro T, Saito H, Suzuki I

Anti-inflammatory and wound healing activity of a growth substance in Aloe vera

Author(s): Davis RH, Donato JJ, Hartman GM, Haas RC

Effect of aloe vera gel to healing of burn wound a clinical and histologic study

Author(s): Visuthikosol V, Chowchuen B, Sukwanarat Y, Sriurairatana S, Boonpucknavig V

Antinociceptive and anti-inflammatory effects of Aloe saponaria Haw on thermal injury in rats

Author(s): Silva MA, Trevisan G, Klafke JZ, Rossato MF, Walker CI, et al.

Role of cytokines in rheumatoid arthritis

Author(s): Feldmann M, Brennan FM, Maini RN