Author(s): Avato P, Bucci R, Tava A, Vitali C, Rosato A, et al.
The antimicrobial activity of saponins from Medicago sativa, M. arborea and M. arabica against a selection of medically important yeasts, Gram-positive and -negative bacteria was investigated. Structure-activity growth inhibitory effects of related prosapogenins and sapogenins are also described. Increasing antibiotic activity was observed going from the saponin extracts to the sapogenin samples, suggesting that the sugar moiety is not important for the antimicrobial efficacy. Activity was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae. The observed antimicrobial properties of M. sativa and M. arborea were related to the content of medicagenic acid, while hederagenin seems to contribute to the bioactivity of M. arabica total sapogenins.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/16619355
Author(s): Malinow MR, McLaughlin P, Papworth L, Stafford C, Kohler GO, et al.
Author(s): D’Addabbo T, Curto G, Greco P, Di Silvestro D, Coiro MI, et al.
Author(s): Pelah D, Abramovich Z, Markus A, Wiesman Z
Author(s): Argentieri MP, Addabbo TD, Tava A, Agostinelli A, Jurzysta M, et al.
Author(s): Tava A, Mella M, Avato P, Argentieri MP, Bialy Z, et al.
Author(s): Tava A, Avato P
Author(s): Bialy Z, Jurzysta M, Mella M, Tava A
Author(s): Allain CC, Poon LS, Chan CS, Richmond W, Fu PC
Author(s): San Martin R, Magnunacelaya JC
Author(s): Chitwood DJ
Author(s): Francis G, Kerem Z, Makkar HP, Becker K
Author(s): Merris M, Wadsworth WG, Khamrai U, Bittman R, Chitwood DJ, et al.
Author(s): Heng L, Koningsveld van GA, Gruppen H, Boekel van MAJS, Vincken JP, et al.
Author(s): Ikedo S, Shimoyada M, Watanabe K
Author(s): Potter SM, Jimenez-Flores R, Pollack J, Lone TA, Berber-Jimenez MD
Author(s): Page AP, Winter AD
Author(s): Bialy Z, Jurzysta M, Mella M, Tava A
Author(s): Houghton P, Patel N, Jurzysta M, Biely Z, Cheung C
Author(s): Julier B, Guy P, Castillo-Acuna C, Caubel G, Ecalle C, et al.
Author(s): Jurzysta M, Price K, Ridout C, Fenwick R
Author(s): Morein B, Hu KF, Abusugra I
Author(s): Oleszek W, Jurzysta M, Ploszynski M, Colquhoun IJ, Price KR, et al.
Author(s): Pedersen MW, Barnes DK, Sorensen EL, Griffin DG, Nielson MW, et al.
Author(s): Raski DJ
Author(s): Rönnberg B, Fekadu M, Morein B
Author(s): Tanaka O, Tamura Y, Masuda H, Mizutani K
Author(s): Tava A, Oleszek W, Jurzysta M, Berardo N, Odoardi M
Author(s): Kurzchalia TV, Ward S
