Antinociceptive and anti-inflammatory effects of Aloe saponaria Haw on thermal injury in rats

Author(s): Silva MA, Trevisan G, Klafke JZ, Rossato MF, Walker CI, et al.


Ethnopharmacological relevance

In Brazil, the plant Aloe saponaria Haw, popularly known as “babosa pintadinha”, has been empirically used for its potential effect on thermal injury. Because there are no scientific data confirming its popular use, the aim of the present study was to investigate the effects of Aloe saponaria on nociceptive and inflammatory parameters in a rat model of thermal injury.

Materials and methods

Adult male Wistar rats were subjected to a thermal injury or sham procedure (immersion in water at 70 or 37 °C, respectively, for 5 or 8 s). Burned animals were topically treated with vehicle (base cream), sulfadiazine 1% (positive control) or Aloe saponaria cream (0.3%–30%) once a day for 2 or 6 days. Each day, 30 min before the treatment, we measured nociceptive (static and dynamic mechanical allodynia, thermal allodynia and spontaneous pain) and inflammatory (paw edema) parameters. Moreover, enzymatic indicators of leukocyte infiltration into burned tissue were also determined 2 or 6 days after the thermal injury.

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