Antioxidant, anti-lipoxygenase and cytotoxic activity of Leptadenia pyrotechnica (Forssk

Author(s): Khasawneh MA, Elwy HM, Hamza AA, Fawzi NM, Hassan AH


Leptadenia pyrotechnica Forssk is a traditional medicinal herb used for treatment of inflammatory diseases and cancer. In this research, the aqueous ethanolic crude extract of Leptadenia pyrotechnica aerial parts, along with its ethyl acetate, n-butanol and water partitioning fractions were evaluated for their antioxidant capacity, polyphenolic content, anti-inflammatory and anti-cancer properties. The total antioxidant capacity was estimated by the FRAP, DPPH, ABTS and β-carotene bleaching assays.The ethyl acetate fraction exhibited the highest polyphenolic content (252.27 mg gallic acid/g) and the best antioxidant activity (1.2, 0.57, 0.45 mmol ascorbic acid equivalent/g in the FRAP, ABTS and DPPH assays, respectively). Furthermore, the same extract showed appreciable anti-inflammatory via lipoxygenase (LOX) inhibitory activity (IC₅₀ = 1.41 µg/mL). Moreover, the ethyl acetate fraction also showed the strongest cytotoxic effect (IC₅₀ = 43.16 µg/mL) against MCF-7 human breast cancer cell line. These results suggest that this plant may be considered an interesting source of compounds with antioxidant, anti-inflammatory and anti-cancer properties for therapeutic, nutraceutical and functional food applications.

Similar Articles

Colorectal cancer screening - methodology

Author(s): Jenkinson F, Steele RJ

Leptadenia pyrotechnica (Forssk

Author(s): El Ghonemy AA

Pregnane glycosides from Leptadenia pyrotechnica

Author(s): Cioffi G, Sanogo R, Vassallo A, Dal Piaz F, Autore G, et al.

The p53 network: p53 and its downstream genes

Author(s): Shu KX, Li B, Wu LX

The role of the Bcl-2 protein family in cancer

Author(s): Coultas L, Strasser A

Diterpenes from the leaves of Croton zambesicus

Author(s): Block S, Baccelli C, Tinant B, Van Meervelt L, Rozenberg R, et al.

Biological effects of conjugated linoleic acids in health and disease

Author(s): Bhattacharya A, Banu J, Rahman M, Causey J, Fernandes G