Antioxidant xanthones from Swertia mussotii, a high Altitude plant

Author(s): Luo CT, Mao SS, Liu FL, Yang MX, Chen H, et al.


Four new xanthones, 3,5,6,8-tetrahydroxyxanthone-1-C-β-d-glucoside (1), 7-hydroxy-3,4,8-trimethoxyxanthone-1-O-(β-d-glucoside) (2), 6-hydroxy-3,5-dimethoxyxanthone-1-O-(β-d-glucoside) (3), 3,4,7,8-tetramethoxyxanthone-1-O-(β-d-glucoside) (4), together with twenty-one known xanthones (525) were isolated from the ethanol aqueous extract of Swertia mussotii. Their structures were elucidated via spectroscopic analyses. Oxygen radical absorbance capacity of all the isolated xanthones was systematically evaluated by ORACFL assay. Results disclose that all the tested xanthones display moderate to excellent antioxidant activity, where 1 is the most active compound and 13 is the least one. A preliminary structure–activity relationship is also discussed.

Graphical abstract

Four new xanthones, together with 21 known xanthones have been isolated from Swertia mussotii. Antioxidant capacity of all compounds was evaluated by ORACFL assay.

Similar Articles

Tibetan Medicine

Author(s): Yang YC

Studies on chemical constituents of Swertia mussotii

Author(s): Zhang JS, Wang XM, Dong XH, Yang HY, Li GP

Studies on Chemical Constituents in Swertia mussotii Franch

Author(s): Shang J, Zhang GY, Yang CB, Chen Z

Swertia (Gentianaceae): chemical and pharmacological aspects

Author(s): Brahmachari G, Mondal S, Gangopadhyay A, Gorai D, Mukhopadhyay B, et al.

The glucosides from Swertia Mussotii Franch

Author(s): Sun HF, Hu BL, Ding JY, Fan SF

Polyanxanthone A, B and C, three xanthones from the wood trunk of Garcinia polyantha Oliv

Author(s): Louh GN, Lannang AM, Mbazoa CD, Tangmouo JG, Komguem J, et al.

Xanthones inhibitors of α-glucosidase and glycation from Garcinia nobilis

Author(s): Fouotsa H, Lannang AM, Mbazoa CD, Rasheed S, Marasini BP, et al.

Xanthones from Swertia mussotii and their α-glycosidase inhibitory activities

Author(s): Luo CT, Zheng HH, Mao SS, Yang MX, Luo C, et al.