Anxiolytic-like effect of the monoterpene 1,4-cineole in mice

Author(s): Gomes PB, Feitosa ML, Silva MI, Noronha EC, Moura BA, et al.


Recent studies have shown that some monoterpenes exert anxiolytic- and depressant-like actions, however, these effects from monoterpene 1,4-cineole are still unknown. This work aimed to study the effects of 1,4-cineole in classic animal models for depression- and anxiety-like behavior, specifically the elevated plus maze (EPM), hole board, open field, pentobarbital sleeping time, forced swimming, tail suspension and rota rod tests. 1,4-Cineole was administered orally to mice (100, 200 and 400 mg/kg), while diazepam (1 or 2 mg/kg) and imipramine (10 or 30 mg/kg) were used as standard drugs. 1,4-Cineole (400 mg/kg) modified all parameters observed in the EPM, while no significant variation was observed on general motor activity in the open-field test. In the hole-board assay, 1,4-cineole induced increase on the number of head dips. Forced swimming and tail suspension tests showed that cineole (200 and/or 400 mg/kg) was able to promote significant increase on the immobility time, while a decreased sleep latency was observed (200 and 400 mg/kg ) on the pentobarbital sleeping time. Cineole had no effect on the motor coordination of animals in the rota rod test. The results suggest that 1,4-cineole presents potential anxiolytic-like action consistent with possible general depression of the CNS.

Similar Articles

Anxiety and Its Disorders

Author(s): Barlow DH

The anxiolytic-like effects of Aloysia polystachya (Griseb

Author(s): Hellión-Ibarrola MC, Ibarrola DA, Montalbetti Y, Kennedy ML, Heinichen O, et al.

The encyclopedia of essential oils

Author(s): Lawless J

Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats

Author(s): Shaw D, Annett JM, Doherty B, Leslie JC

Anxiolytic-like effects of rose oil inhalation on the elevated plus-maze test in rats

Author(s): Almeida RN, Motta SC, Faturi CB, Catallani B, Leite JR

Effects of the essential oil from Citrus aurantium L

Author(s): Pultrini AM, Galindo LA, Costa M

Interspecies comparison of chemical composition and anxiolytic-like effects of lavender oils upon inhalation

Author(s): Takahashi M, Satou T, Ohashi M, Hayashi S, Sadamoto K, et al.

Effects of inhaled Linalool in anxiety, social interaction and aggressive behavior in mice

Author(s): Linck VM, da Silva AL, Figueiró M, Caramão EB, Moreno PR, et al.

Anxiolytic-like effect of Carvacrol (5-isopropyl-2-methylphenol) in mice: involvement with GABAergic transmission

Author(s): Melo FH, Venâncio ET, de Sousa DP, de França Fonteles MM, de Vasconcelos SM, et al.

Central nervous system activity of acute administration of isopulegol in mice

Author(s): Silva MI, de Aquino Neto MR, Teixeira Neto PF, Moura BA, do Amaral JF, et al.

Anxiolytic-like effect of sweet orange aroma in Wistar rats

Author(s): Faturi CB,Leite JR,Alves PB,Canton AC,Teixeira-Silva F

Effect of sweet orange aroma on experimental anxiety in humans

Author(s): Goes TC,Antunes FD,Alves PB,Teixeira-Silva F