Author(s): Longeon A, Copp BR, Quévrain E, Roué M, Kientz B, et al.
Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A₂ (PLA₂), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA₂ inhibition (IC₅₀ 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/21673896
Author(s): Haefner B
Author(s): Belarbi el H, Contreras Gómez A, Chisti Y, García Camacho F, Molina Grima E
Author(s): Sipkema D, Franssen MC, Osinga R, Tramper J, Wijffels RH
Author(s): Alcaraz MJ, Payá M
Author(s): Paul VJ
Author(s): Green G
Author(s): Proksch P
Author(s): Taylor MW, Radax R, Steger D, Wagner M
Author(s): Stowe SD, Richards JJ, Tucker AT, Thompson R, Melander C, et al.
Author(s): Thompson JE, Walker RP, Faulkner DJ
Author(s): Beccero MA, Turon X, Uriz MJ
Author(s): Becerro MA, Thacker RW, Turon X, Uriz MJ, Paul VJ
Author(s): Muller WEG
Author(s): Lavrov D
Author(s): By Phil Myers
Author(s): Molinski TF, Dalisay DS, Lievens SL, Saludes JP
Author(s): Simmons TL, Andrianasolo E, McPhail K, Flatt P, Gerwick WH
Author(s): Gordaliza M
Author(s): Hallock YF, Cragg GM
Author(s): Hildebrand M, Waggoner LE, Lim GE, Sharp KH, Ridley CP, et al.
Author(s): Baker DD, Chu M, Oza U, Rajgarhia V
Author(s): Newman DJ, Cragg GM
Author(s): Newman DJ, Cragg GM
Author(s): Sagar S, Kaur M, Minneman KP
Author(s): Villa FA, Gerwick L
Author(s): Frota MJ, Silva RB, Mothes B, Henriques AT, Moreira JC
Author(s): Blunt JW, Copp BR, Keyzers RA, Munro MH, Prinsep MR
Author(s): Shaaban M, Abd-Alla HI, Hassan AZ, Aly HF, Ghani MA
Author(s): Utkina NK
Author(s): Li Z
Author(s): Sugiyama Y, Ito Y, Suzuki M, Hirota A
Author(s): Kim SK, Dewapriya P
Author(s): Berrué F, McCulloch MW, Boland P, Hart S, Harper MK, et al.
Author(s): Abraham I, El Sayed K, Chen ZS, Guo H
Author(s): Mayer AM, Glaser KB, Cuevas C, Jacobs RS, Kem W, et al.
Author(s): Crews P, Gewick WH, Schmitz FJ, France D, Bair KW, et al.
Author(s): Wang YQ, Miao ZH
Author(s): Bergmann W, Feeney RJ
Author(s): Proksch P, Edrada RA, Ebel R
Author(s): Schwartsmann G
Author(s): Feldman EJ, Lancet JE, Kolitz JE, Ritchie EK, Roboz GJ, et al.
Author(s): Essack M, Bajic VB, Archer JA
Author(s): Sipkema D, Osinga R, Schatton W, Mendola D, Tramper J, et al.
Author(s): Newman DJ, Cragg GM
Author(s): Halim H, Chunhacha P, Suwanborirux K, Chanvorachote P
Author(s): Guzii AG, Makarieva TN, Denisenko VA, Dmitrenok PS, Kuzmich AS, et al.
Author(s): Kondracki ML, Guyot M
Author(s): Kong D, Yamori T, Kobayashi M, Duan H
Author(s): Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E
Author(s): Rothmeier AS, Schneiders UM, Wiedmann RM, Ischenko I, Bruns CJ, et al.
Author(s): Valeriote FA, Tenney K, Media J, Pietraszkiewicz H, Edelstein M, et al.
Author(s): Rabelo L, Monteiro N, Serquiz R, Santos P, Oliveira R, et al.
Author(s): Schumacher M, Cerella C, Eifes S, Chateauvieux S, Morceau F, et al.
Author(s): Shin BA, Kim YR, Lee IS, Sung CK, Hong J, et al.
Author(s): Zhao Q, Mansoor TA, Hong J, Lee CO, Im KS, et al.
Author(s): Gunasekera SP, Cranick S, Longley RE
