Author(s): Forgo P, Zupkó I, Molnár J, Vasas A, Dombi G, et al.
Bioassay-guided fractionation of the chloroform extract of Centaurea jacea L. afforded the isolation of cirsiliol, apigenin, hispidulin, eupatorin, isokaempferide, axillarin, centaureidin, 6-methoxykaempferol 3-methyl ether, trachelogenin, cnicin, 4'-acetylcnicin and three aliphatic glucose diesters, including the new natural product 1β-isobutanoyl-2-angeloyl-glucose. The structures of the compounds were established on the basis of spectroscopic analyses (UV, MS and NMR). All compounds were isolated for the first time from this species. The compounds were evaluated for their tumour cell growth inhibitory activities on HeLa, MCF-7 and A431 cells. Different types of secondary metabolites (flavonoids, sesquiterpenes) were found to be responsible for the antitumour effects of the extracts; the highest activity was exerted by centaureidin, in addition to moderately active compounds (cirsiliol, isokaempferide, apigenin, hispidulin, cnicin and 4'-acetylcnicin).
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/22537643
Author(s): Young AM
Author(s): Dillinger TL, Barriga P, Escárcega S, Jimenez M, Salazar Lowe D, et al.
Author(s): Corti R, Flammer AJ, Hollenberg NK, Lüscher TF
Author(s): Sánchez-Rabaneda F, Jáuregui O, Casals I, Andrés-Lacueva C, Izquierdo-Pulido M, et al.
Author(s): Yamagishi M, Natsume M, Osakabe N, Okazaki K, Furukawa F, et al.
Author(s): Kenny T, Keen C, Jones P, Kung H, Schmitz H, et al.
Author(s): Kang NJ, Lee KW, Lee DE, Rogozin EA, Bode AM, et al.
Author(s): Carnésecchi S, Schneider Y, Lazarus SA, Coehlo D, Gossé F, et al.
Author(s): Ramljak D, Romanczyk LJ, Metheny-Barlow LJ, Thompson N, Knezevic V, et al.
Author(s): Lee KW, Kim YJ, Lee HJ, Lee CY
Author(s): Martin MA, Goya L, Ramos S
Author(s): Abdah MA, Ling LC, Rahmat A, Zakaria ZA
Author(s): Pan L, Lantvit DD, Riswan S, Kardono LB, Chai HB, et al.
Author(s): Ludwiczuk A, Saha A, Kuzuhara T, Asakawa Y
Author(s): Lai CS, Mas RH, Nair NK, Majid MI, Mansor SM, et al.
Author(s): Ode OJ, Asuzu IU, Ajayi IE
Author(s): Hema R, Kumaravel S, Gomathi S, Sivasubramaniam C
Author(s): Atjanasuppat K, Wongkham W, Meepowpan P, Kittakoop P, Sobhon P, et al.
Author(s): Mani S, Krishnaswamy M
Author(s): Karagoz A, Turgut-Kara N, Cakir O, Demirgan R, Ari S
Author(s): Chan SW, Lee CY, Yap CF, Wan Aida WM, Ho CW