Chemistry and biological activity of triterpene saponins from Medicago species

Author(s): Tava A, Avato P


Ten triterpenoid glycosides have been isolated from the roots of Medicago sativa L. (Leguminosae) including eight new glycosides and two previously known, medicagenic acid 3-O-beta-D-glucopyranoside and hederagenin 3-O-[beta-D-glucopyranosyl(1-->2)-alpha-L-arabinopyranoside]. Four new saponins were identified as glycosides of medicagenic acid, four from hederagenin. Their structures were elucidated by a combination of chemical and spectroscopic techniques (IR, EI/MS, NMR 1H and 13C). In some cases we used fast atom bombardment mass spectra (FAB/MS), NMR 1H difference spectra (homonuclear double resonance, Overhauser effect), NMR 13C partially decoupled spectra (off resonance), and two-dimensional 1H-1H correlating spectra (COSY 1H-1H). The inhibitory effects of these glycosides on growth and seed germinations and on some phytopathogenic bacteria have also been tested.

Similar Articles

Effect of alfalfa saponins on intestinal cholesterol absorption in rats

Author(s): Malinow MR, McLaughlin P, Papworth L, Stafford C, Kohler GO, et al.

Preliminary trials with extracts of Quillaja saponaria Molina for the control of root-knot nematodes

Author(s): D’Addabbo T, Curto G, Greco P, Di Silvestro D, Coiro MI, et al.

Evaluation of nematicidal properties of saponins from Medicago spp

Author(s): Argentieri MP, Addabbo TD, Tava A, Agostinelli A, Jurzysta M, et al.

Triterpenoid glycosides from leaves of Medicago arborea L

Author(s): Tava A, Mella M, Avato P, Argentieri MP, Bialy Z, et al.

Triterpene saponins from aerial parts of Medicago arabica L

Author(s): Bialy Z, Jurzysta M, Mella M, Tava A

Antimicrobial activity of saponins from Medicago sp

Author(s): Avato P, Bucci R, Tava A, Vitali C, Rosato A, et al.

Enzymatic determination of total serum cholesterol

Author(s): Allain CC, Poon LS, Chan CS, Richmond W, Fu PC

The biological action of saponins in animal systems: a review

Author(s): Francis G, Kerem Z, Makkar HP, Becker K

Protein-flavour interactions in relation to development of novel protein foods

Author(s): Heng L, Koningsveld van GA, Gruppen H, Boekel van MAJS, Vincken JP, et al.

Protein- saponin interaction and its influence on blood lipids

Author(s): Potter SM, Jimenez-Flores R, Pollack J, Lone TA, Berber-Jimenez MD

Triterpene saponins from the roots of Medicago hybrida

Author(s): Bialy Z, Jurzysta M, Mella M, Tava A

Zanhic acid tridesmoside and other dominant saponins from Alfalfa (Medicago sativa L.) aerial parts.

Author(s): Oleszek W, Jurzysta M, Ploszynski M, Colquhoun IJ, Price KR, et al.

Dagger and needle nematodes

Author(s): Raski DJ

Alfalfa saponins and sapogenins: Isolation and quantification in two different cultivars

Author(s): Tava A, Oleszek W, Jurzysta M, Berardo N, Odoardi M