Colorectal cancer screening - methodology

Author(s): Jenkinson F, Steele RJ


Colorectal cancer (CRC) is a major problem worldwide with the highest incidence being found in developed countries, and is the 3rd most common cancer in Scotland. Patients do not generally have symptoms related to CRC until late in the disease process, so there has been much interest in developing screening programmes to detect CRC early. Most commonly, screening involves the identification of occult blood in stool samples. Alternatives include flexible sigmoidoscopy, colonoscopy, radiological investigation and the identification of DNA mutations or proteins in stool. Candidate markers for mutation identification are K-ras, BRAF, p53 and APC which may be used alone or in combination to identify those with colorectal cancer.

Similar Articles

Leptadenia pyrotechnica (Forssk

Author(s): El Ghonemy AA

Pregnane glycosides from Leptadenia pyrotechnica

Author(s): Cioffi G, Sanogo R, Vassallo A, Dal Piaz F, Autore G, et al.

Antioxidant, anti-lipoxygenase and cytotoxic activity of Leptadenia pyrotechnica (Forssk

Author(s): Khasawneh MA, Elwy HM, Hamza AA, Fawzi NM, Hassan AH

The p53 network: p53 and its downstream genes

Author(s): Shu KX, Li B, Wu LX

The role of the Bcl-2 protein family in cancer

Author(s): Coultas L, Strasser A

Diterpenes from the leaves of Croton zambesicus

Author(s): Block S, Baccelli C, Tinant B, Van Meervelt L, Rozenberg R, et al.

Biological effects of conjugated linoleic acids in health and disease

Author(s): Bhattacharya A, Banu J, Rahman M, Causey J, Fernandes G