Author(s): Schulz C, Obermüller-Jevic UC, Hasselwander O, Bernhardt J, Biesalski HK
The relative bioavailability of coenzyme Q10 (CoQ10) is markedly influenced by its delivery systems. The aim of this study was to compare four standard CoQ10 supplements available on the market with a novel solubilizate formulation of CoQ10 (Solu Q10). Pharmacokinetic parameters were assessed in 54 healthy volunteers after single and multiple intakes of 60 mg CoQ10 over a time period of 14 days. Solubilizates showed earlier flooding compared with oily dispersions and crystalline CoQ10, resulting in significantly elevated area under the curve between 0 and 4 h (P<0.01 solubilizates versus crystalline). The difference in the pharmacokinetic parameters of maximum plasma concentration, time to reach the peak plasma concentration and area under the curve between 0 and 12 h was not statistically significant between formulations. Long-term supplementation resulted in significantly higher plasma levels (P<0.01) for all formulations, with Solu Q10 performing best. Intracellular CoQ10 levels measured in buccal mucosa cells were increased (P<0.05) in response to supplementation when starting within the physiological range. In summary, solubilizates were clearly superior to oily dispersions and crystalline CoQ10 in their overall bioavailability, with the best absorption characteristics seen for the novel Solu Q10 solubilizate.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17162333
Author(s): Mortensen SA, Leth A, Agner E, Rohde M
Author(s): Langsjoen P, Langsjoe A
Author(s): Freye E
Author(s): Spackman TN, Faust RJ, Cucchiara RF, Sharbrough FW
Author(s): Freye E, Dehnen-Seipel H, Latasch L, Behler M, Wilder-Smith OH
Author(s): Freye E, Fournell A
Author(s): Oken B, Salinsky MC, Siegward ME
Author(s): Shults CW, Bealc MF, Songa D, Fontaine D
Author(s): Beal MF
Author(s): Madmani M, Yusuf Solaiman A, Tamr Agha K, Madmani Y, Shahrour Y, et al.
Author(s): Omran H, St Cyr J, Lüderitz B
Author(s): Freye E, Strobel HP
Author(s): Choi CH, Kang G, Min YD
Author(s): Chen J, Raymond K
Author(s): Weeß HG, Lund R, Gresele C, Böhning W, Sauter C, et al.
Author(s): Crane FL
Author(s): Chopra RK, Goldman R, Sinatra ST, Bhagavan HN
Author(s): Weis M, Mortensen SA, Rassing MR, Møller-Sonnergaard J, Poulsen G, et al.
Author(s): Molyneux S, Florkowski C, Lever M, George P
Author(s): Liu ZX, Artmann C