Author(s): El-Azab AS, Eltahir KE
A novel series of 7-substituted-4(3H)-quinazolinone were designed, synthesized and evaluated for their antitumor and anticonvulsant activity. Compound 7 revealed broad-spectrum antitumor effectiveness toward numerous cell lines that belong to different tumor subpanels, whereas compounds 9 and 18 possess selective activity toward leukemia cell lines. Additionally, compounds 3, 15, 16, 18, 19 and 20 showed advanced anticonvulsant activity as well as lower neurotoxicity than reference drugs. The achieved results proved that the distinctive compounds could be valuable as a model for future devise, acclimatization and investigation to construct more active analogues.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/22326394
Author(s): Xu Z, Zhang Y, Fu H, Zhong H, Hong K, et al.
Author(s): Moghimi A, Khanmiri RH, Omrani I, Shaabani A
Author(s): Mashraqui SH, Ghorpade SS, Tripathi S, Britto S
Author(s): Duan Y, Zhu XY, Ma JA, Zhou YG
Author(s): Motegi M, Nugroho AE, Hirasawa Y, Arai T, Hamid A, et al.
Author(s): Lu L, Zhang MM, Jiang H, Wang XS
Author(s): Wang Z, Wang M, Yao X, Li Y, Tan J, et al.
Author(s): Ramesh G, Narender P, Venkateshwarlu G, Avinash BC, VenkataRao C, et al.
Author(s): Yadav AK, Dhakad P, Sharma GR
Author(s): Yadav MR, Grande F, Chouhan BS, Naik PP, Giridhar R, et al.