Design and synthesis of novel 7-aminoquinazoline derivatives: antitumor and anticonvulsant activities

Author(s): El-Azab AS, Eltahir KE


A novel series of 7-substituted-4(3H)-quinazolinone were designed, synthesized and evaluated for their antitumor and anticonvulsant activity. Compound 7 revealed broad-spectrum antitumor effectiveness toward numerous cell lines that belong to different tumor subpanels, whereas compounds 9 and 18 possess selective activity toward leukemia cell lines. Additionally, compounds 3, 15, 16, 18, 19 and 20 showed advanced anticonvulsant activity as well as lower neurotoxicity than reference drugs. The achieved results proved that the distinctive compounds could be valuable as a model for future devise, acclimatization and investigation to construct more active analogues.

Similar Articles

Antifungal quinazolinones from marine-derived Bacillus cereus and their preparation

Author(s): Xu Z, Zhang Y, Fu H, Zhong H, Hong K, et al.

Leucomidines A–C, novel alkaloids from Leuconotisgriffithii

Author(s): Motegi M, Nugroho AE, Hirasawa Y, Arai T, Hamid A, et al.

Design, synthesis and antiviral activity of novel quinazolinones

Author(s): Wang Z, Wang M, Yao X, Li Y, Tan J, et al.

Pd-catalyzed amination of 6-halo-2-cyclopropyl-3-(pyridyl-3-ylmethyl) quinazolin-4(3H)-one

Author(s): Ramesh G, Narender P, Venkateshwarlu G, Avinash BC, VenkataRao C, et al.

Cytotoxic potential of novel 6,7-dimethoxyquinazolines

Author(s): Yadav MR, Grande F, Chouhan BS, Naik PP, Giridhar R, et al.