Dietary vitamin E and selenium and toxicity of nitrite and nitrate

Author(s): Chow CK, Hong CB


Nitrites and nitrates are important antimicrobial and flavoring/coloring agents in meat and fish products. However, nitrites and nitrates may cause methemoglobinemia and other illness, and may react with certain amines to form carcinogenic nitrosamines. The nutritional status of vitamin E and selenium has long been associated with nitrite and nitrate toxicity, although the mechanism involved is not yet clear. Information available recently shows that nitrites and nitrates are both oxidation products and ready sources of nitric oxide (NO*), that NO* reacts rapidly with superoxide to form highly reactive peroxynitrite (ONOO-), and that vitamin E may mediate the generation and availability of superoxide and NO*. Increased formation of ONOO- resulting from nitrite treatment and low intake of vitamin E and selenium may thus be the critical event leading to tissue damage and animal mortality observed previously. The protection against the adverse effects of nitrites/nitrates by vitamin E is attributed to its ability to reduce ONOO- formation, while selenium exerts its protective effects via seleno-enzymes/compounds, which reduce ONOO- formed.

Similar Articles

Tibetan Medicine

Author(s): Yang YC

Studies on chemical constituents of Swertia mussotii

Author(s): Zhang JS, Wang XM, Dong XH, Yang HY, Li GP

Studies on Chemical Constituents in Swertia mussotii Franch

Author(s): Shang J, Zhang GY, Yang CB, Chen Z

Swertia (Gentianaceae): chemical and pharmacological aspects

Author(s): Brahmachari G, Mondal S, Gangopadhyay A, Gorai D, Mukhopadhyay B, et al.

The glucosides from Swertia Mussotii Franch

Author(s): Sun HF, Hu BL, Ding JY, Fan SF

Polyanxanthone A, B and C, three xanthones from the wood trunk of Garcinia polyantha Oliv

Author(s): Louh GN, Lannang AM, Mbazoa CD, Tangmouo JG, Komguem J, et al.

Xanthones inhibitors of α-glucosidase and glycation from Garcinia nobilis

Author(s): Fouotsa H, Lannang AM, Mbazoa CD, Rasheed S, Marasini BP, et al.

Antioxidant xanthones from Swertia mussotii, a high Altitude plant

Author(s): Luo CT, Mao SS, Liu FL, Yang MX, Chen H, et al.

Xanthones from Swertia mussotii and their α-glycosidase inhibitory activities

Author(s): Luo CT, Zheng HH, Mao SS, Yang MX, Luo C, et al.