Drug interactions between herbs and medicines: Hypericum perforatum and Piper methysticum

Author(s): Cordeiro CHG, Chung MC, Sacramento LVS


The use of natural products in folk medicine dates back thousands of years and persists to the present day. However, the idea that these products are free of toxicity makes the use of herbal medicines increasingly widespread and indiscriminate. This work is a review of the interactions that may occur with the concomitant use of Hypericum perforatum L. (St. John's wort) and Piper methysticum F. (kava-kava) with drugs, which can lead to serious toxic effects, including fatality. .

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