Effect of aqueous leaves extract of Cordiadichotomaon blood glucose levels of normoglycemic&alloxan induced diabetic wister rats

The effect of the aqueous extract of alloxan induced and normoglycemic Wister rats has been investigated. Three doses of the extract (250 mg/kg; 500 mg/kg and 1000 mg/kg) were administered orally. The 500 mg/kg extract of Cordia Dichotoma did not show any significant change in the blood glucose levels in normoglycemic and 250 mg/kg did not show any significant change in the blood glucose levels in alloxan Induced Diabetic Wister rats, when compared to untreated control. The dose 500 & 1000 mg/kg of extract showed a significant (p<0.5) decrease in blood glucose levels after 4, 8 and 24 hours. In normoglycemic rats, the dose of 1000 mg/kg of the extract significantly (p<0.05) decrease the blood glucose levels at 8 and 24 hours. In conclusion, the doses of extract has shown both significant (p<0.05) hypoglycemic and antihyperglycemic effects in Wister rats.