Effect of aqueous leaves extract of Cordiadichotomaon blood glucose levels of normoglycemic&alloxan induced diabetic wister rats

Author(s): Gaurav S, Navneet N, Sandeep R, Singh P, Porwal A, et al.


The effect of the aqueous extract of alloxan induced and normoglycemic Wister rats has been investigated. Three doses of the extract (250 mg/kg; 500 mg/kg and 1000 mg/kg) were administered orally. The 500 mg/kg extract of Cordia Dichotoma did not show any significant change in the blood glucose levels in normoglycemic and 250 mg/kg did not show any significant change in the blood glucose levels in alloxan Induced Diabetic Wister rats, when compared to untreated control. The dose 500 & 1000 mg/kg of extract showed a significant (p<0.5) decrease in blood glucose levels after 4, 8 and 24 hours. In normoglycemic rats, the dose of 1000 mg/kg of the extract significantly (p<0.05) decrease the blood glucose levels at 8 and 24 hours. In conclusion, the doses of extract has shown both significant (p<0.05) hypoglycemic and antihyperglycemic effects in Wister rats.

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