Author(s): Calixto JB
This review highlights the current advances in knowledge about the safety, efficacy, quality control, marketing and regulatory aspects of botanical medicines. Phytotherapeutic agents are standardized herbal preparations consisting of complex mixtures of one or more plants which contain as active ingredients plant parts or plant material in the crude or processed state. A marked growth in the worldwide phytotherapeutic market has occurred over the last 15 years. For the European and USA markets alone, this will reach about $7 billion and $5 billion per annum, respectively, in 1999, and has thus attracted the interest of most large pharmaceutical companies. Insufficient data exist for most plants to guarantee their quality, efficacy and safety. The idea that herbal drugs are safe and free from side effects is false. Plants contain hundreds of constituents and some of them are very toxic, such as the most cytotoxic anti-cancer plant-derived drugs, digitalis and the pyrrolizidine alkaloids, etc. However, the adverse effects of phytotherapeutic agents are less frequent compared with synthetic drugs, but well-controlled clinical trials have now confirmed that such effects really exist. Several regulatory models for herbal medicines are currently available including prescription drugs, over-the-counter substances, traditional medicines and dietary supplements. Harmonization and improvement in the processes of regulation is needed, and the general tendency is to perpetuate the German Commission E experience, which combines scientific studies and traditional knowledge (monographs). Finally, the trend in the domestication, production and biotechnological studies and genetic improvement of medicinal plants, instead of the use of plants harvested in the wild, will offer great advantages, since it will be possible to obtain uniform and high quality raw materials which are fundamental to the efficacy and safety of herbal drugs.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/10657057
Author(s): Tirona RG, Bailey DG
Author(s): Henderson L, Yue QY, Bergquist C, Gerden B, Arlett P
Author(s): Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo Z
Author(s): Brito AR, Brito AA
Author(s): Wayland C
Author(s): Wayland C
Author(s): Brazilian Ministry of Health
Author(s): Clement YN, Morton-Gittens J, Basdeo L, Blades A, Francis MJ, et al.
Author(s): Dergal JM, Gold JL, Laxer DA, Lee MS, Binns MA, et al.
Author(s): Brazier NC, Levine MA
Author(s): Cordeiro CHG, Chung MC, Sacramento LVS
Author(s): Oliveira SGD, Moura FRR, Demarco FF, Nascente PS, Del Pino FAB, et al.
Author(s): Eisenberg DM, Kessler RC, Foster C, Norlock FE, Calkins DR, et al.
Author(s): Saw JT, Bahari MB, Ang HH, Lim YH
Author(s): Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, et al.
Author(s): Bensoussan A, Myers SP
Author(s): Kuo GM, Hawley ST, Weiss LT, et al.
Author(s): Vendruscolo GS, Mentz LA
Author(s): Brasileiro BG, Pizziolo VR, Matos DS, Germano AM, Jamal CM
Author(s): Mahady GB
Author(s): Kuhn MA
Author(s): Miller LG
Author(s): Seidl PR
Author(s): van Andel T, Westers P