Author(s): Wang D, Hu J, Lv L, Xia X, Liu J, et al.
Curcumin, a traditional medicine, exhibits anticarcinogenic properties in various cell lines and animals. As a phenolic compound, curcumin is light‑sensitive and photoactived curcumin exhibits a greater anticancer effect compared with curcumin alone. However, the mechanisms by which curcumin inhibits tumor cell growth in human nasopharyngeal carcinoma (NPC) cells following purple light (PL) irradiation remains unclear. In the present study, CNE1 and CNE2 cells were treated with curcumin and exposed to PL at various energy densities to determine the anticancer activity of curcumin using MTT assays, staining and flow cytometry. The subsequent changes in the cell viability, morphology, cell cycle, apoptosis and reactive oxygen species (ROS) generation were measured. Curcumin inhibited cell growth in a dose‑dependent manner. CNE1 and CNE2 cells tended to be arrested at the S or G2/M cell cycle stages following curcumin treatment and the levels of ROS increased in a time‑dependent manner. However, after treatment with curcumin followed by PL irradiation, the levels of cytotoxicity and apoptotic cell death were significantly increased compared with the curcumin-only group. ROS generation was also enhanced in an energy‑dependent manner. In summary, following PL irradiation, the anticancer effect of curcumin in human NPC cells was increased through apoptosis and cell cycle arrest.
Referred From: https://www.spandidos-publications.com/10.3892/ol.2013.1341
Author(s): Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, et al.
Author(s): Syu WJ, Shen C, Don MJ, Ou JC, Lee GH, et al.
Author(s): Ahsan H, Parveen N, Khan NU, Hadi SM
Author(s): Ramsewak RS, DeWitt DL, Nair MG
Author(s): Aggarwal BB, Harikumar KB
Author(s): Chandran B, Goel A
Author(s): Lin JK, Pan MH, Lin-Shiau SY
Author(s): Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, et al.
Author(s): Pfeiffera E, Höhlea S, Solyomb AM, Metzlera M
Author(s): Shen L, Ji HF
Author(s): Cheng J, Weijun K, Yun L, Jiabo W, Haitao W, et al.
Author(s): Long Y, Zhang W, Wang F, Chen Z
Author(s): Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK
Author(s): Syed HK, Liew KB, Loh KO, Peh KK
Author(s): Wichitnithad W, Jongaroonngamsang N, Pummangura S, Rojsitthisak P
Author(s): Jadhav BK, Mahadik KR, Paradkar AR
Author(s): Shervington LA, Abba M, Hussain B, Donnelly J