Author(s): Souza JG, Tomei RR, Kanashiro A, Kabeya LM, Azzolini AECS, et al.
Extracts from Alternanthera maritima are used in Brazilian folk medicine for the treatment of infectious and inflammatory diseases. Bioassay-guided fractionation of A. maritima aerial parts yielded an ethanolic crude extract, its butanolic fraction and seven isolated flavonoids (two aglycones, two O-glycosides and three C-glycosides) with antioxidative activity. The ability of these samples to scavenge enzymatically generated free radicals (luminol-horseradish peroxidase-H2O2 reaction) and inhibit reactive oxygen species (ROS) production by opsonized zymosan-stimulated human neutrophils (PMNLs) was evaluated by chemiluminescence methods. In both assays, the butanolic fraction was significantly more active than the ethanolic crude extract, the flavonoid aglycones had high inhibitory activities and the C-glycosylated flavonoids had no significant effect even at the highest concentration tested (50 micromol/L). However, the O-glycosylated flavonoids inhibitory effects on chemiluminescence were strongly dependent on the chemical structure and assay type (cellular or cell-free system). Under the conditions tested, active samples were not toxic to human PMNLs.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/17708437
Author(s): Wang P, Li S, Ownby S, Zhang Z, Yuan W, et al.
Author(s): Salvador MJ, Ferreira EO, Mertens-Talcott SU, De Castro WV, Butterweck V, et al.
Author(s): Cai Y, Sun M, Corke H
Author(s): Li H, Deng Z, Liu R, Zhu H, Draves J, et al.
Author(s): Liu H, Cao J, Jiang W
Author(s): Kumar G, Karthik L, Rao KV
Author(s): Ranju P, Kundlik G, Hitesh G, Thirumoorthy N
Author(s): Biella CA, Salvador MJ, Dias DA, Dias-Baruffi M, Crotti LSP
Author(s): Teixeira CGL, Piccoli A, Costa P, Soares L, Da Silva-Santos JE
Author(s): Freitas CS, Baggio CH, Da Silva-Santos JE, Rieck L, de Moraes Santos CA, et al.
Author(s): Sanoko R, Esperanza G, Pizza C, De Tommasi N
Author(s): Harbone JB
Author(s): Piccinelli AL, De Simone F, Passi S, Rastrelli L
Author(s): Cuendet M, Hostettman K, Potterat O, Dyatmko W
Author(s): Huang D, Ou B, Prior RL
Author(s): Ou B, Hampsch-Woodill M, Prior RL
Author(s): Salvador MJ, de Lourenço CC, Andreazza NL, Pascoal AC, Stefanello ME
Author(s): Ye M, Han J, Chen H, Zheng J, Guo D
Author(s): Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, et al.
Author(s): Pietta PG
Author(s): Rice-Evans CA, Miller NJ, Paganga G
Author(s): Soares SE
Author(s): Zocoler AMD, Sanches ACC, Albrecht I, Mello JCP
Author(s): Custodio L, Fernandes E, Escapa AL, Fajardo A, Aligue R, et al.
Author(s): Salvador MJ, Andreazza NL, Pascoal ACRF, Pereira PS, França SC, et al.
Author(s): Carneiro CS, Costa-Pinto FA, da Silva AP, Pinello KC, da Silva TC, et al.
Author(s): Rao YK, Geethangili M, Fang SH, Tzeng YM
Author(s): Choi HJ, Eun JS, Kim BG, Kim SY, Jeon H, et al.
Author(s): Zhou Y, Liu YE, Cao J, Zeng G, Shen C, et al.
