Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus

Author(s): Irie Y, Itokazu N, Anjiki N, Ishige A, Watanabe K, et al.

Abstract

Here we show that eugenol has an antidepressant-like activity comparable to that of imipramine using a forced swim test and a tail suspension test in mice. Furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (BDNF) in the hippocampus with and without induction of metallothionein-III (MT-III), respectively. It may be possible that MT-III expression is involved in the exhibition of antidepressant-like activity of eugenol, not of imipramine.

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