Author(s): Commarieu A, Hoelderich W, Laffitte JA, Dupont MP
The Fries rearrangement of phenyl acetate for the paracetamol process is usually performed in hydrofluoric acid (HF). We have optimized this reaction with methane sulfonic acid (MSA), a strong, stable and biodegradable acid, to give para-hydroxyacetophenone with high conversion and selectivity (up to 92% of para-isomer and 8% of ortho-isomer at 100% conversion).
Author(s): Siegel H, Eggersdorfer M
Author(s): Muller-Schwarze D, Houlihan PW
Author(s): Sobrinho EV, Cardoso D, Souza-Aguiar EF
Author(s): Munzenberger B, Heilemann J, Strack D, Kottke I, Oberwinkler F
Author(s): Acton QA
Author(s): Mete E, Gul HI, Kazaz C
Author(s): Bernardes CES, Piedade MFM, da Piedade MEM
Author(s): Chaudhary AL, Sheppard DA, Paskevicius M, Pistidda C, Dornheim M, et al.
Author(s): Evans J
Author(s): NIH
Author(s): Garland SN, Valentine D, Desai K, Li S, Langer C, et al.
Author(s): Rubik B
Author(s): Shinde V, Sances F, Patil S, Spence A
Author(s): Sances F, Flora E, Patil S, Spence A, Shinde V
