Hypoglycemic activity of Salvia fruticosa Mill

Author(s): Perfumi M, Arnold N, Tacconi R


Salvia fruticosa Mill. has a folk reputation in the eastern Mediterranean region as a hypoglycemic agent. In order to confirm this claim, a 10% infusion of its leaves was tested, at an oral dose of 0.250 g/kg b.w.t., on normoglycemic rabbits and in rabbits made hyperglycemic by alloxan administration. This oral dose caused a statistically significant reduction in blood glucose levels in alloxanhyperglycemic rabbits, but not in normoglycemic animals, only after repeated administrations of the infusion (once a day for 7 consecutive days). Instead, the hypoglycemic effect was evoked by single oral doses of infusion in both normoglycemic and alloxanhyperglycemic rabbits orally loaded with glucose. However, in these animals S. fruticosa infusion did not modify plasma insulin levels. Moreover, the hypoglycemic effect of the drug was not evoked in rabbits which received the glucose load intravenously. These data strongly suggest that S. fruticosa treatment produces hypoglycemia mainly by reducing intestinal absorption of glucose.

Similar Articles

Antidiabetic potential of Butea monosperma in rats

Author(s): Somani R, Kasture S, Singhai AK

Plants as source of drugs

Author(s): Rates SM

Flavonoids from Centaurea clementei

Author(s):  I Gonzalez Collado, FA Macias, GM Massanet, F Rodriguez Luis

A new flavonoid glycoside from Centaurea horrida

Author(s): Flamini G, Bulleri C, Morelli I, Manunta A

Medicinal plants with hypoglycemic activity

Author(s): Atta-Ur-Rahman, Zaman K

Physicochemical and functional properties of barley ß-glucan as affected by different extraction procedures

Author(s): Asif Ahmad, Faqir Muhammad Anjum, Tahir Zahoor, Haq Nawaz, Ahmad Din

The juice of fresh leaves of Catharanthus roseus Linn

Author(s): Nammi S, Boini MK, Lodagala SD, Behara RB

Protective effects of Origanum majorana L

Author(s): Karim M Raafat, Hasan Jassar, Maha Aboul-Ela, Abdalla El-Lakany

Synergistic Inhibition of Glycinergic Transmission In Vitro and In Vivo by Flavonoids and Strychnine

Author(s): Raafat K, Breitinger U, Mahran L, Ayoub N, Breitinger HG

5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice

Author(s): Ulugol A, Oltulu C, Gunduz O, Citak C, Carrara R, et al.

Effects of in vivo antioxidant enzyme activities of myrtle oil in normoglycaemic and alloxan diabetic rabbits

Author(s): Sepici-Dincel A, Açikgöz S, Cevik C, Sengelen M, Yesilada E