Author(s): Jantan I, Juriyati J, Warif NA
Nine naturally occurring xanthones were investigated for their platelet activating factor (PAF) receptor binding inhibitory effects using rabbit platelets. 2-(3-methylbut-2-enyl)-1,3,5-trihydoxyxanthone, macluraxanthone, 1,3,5-trihydroxy-6,6'-dimethylpyrano(2',3':6,7)-4-(1,1-dimethylprop-2-enyl)xanthone, 6-deoxyjacareubin and 2-(3-methylbut-2-enyl)-1,3,5,6-terahydroxyxanthone showed strong inhibition with IC50 values of 4.8, 11.0, 21.0, 29.0 and 44.0 microM, respectively. The prenyl group at C-2, the dimethylprop-2-enyl group at C-4 and the hydroxyl group at C-5 are all beneficial to the binding of xanthones to the PAF receptor. The results revealed that xanthones can represent a new class of natural PAF receptor antagonists.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/11297865
Author(s): McKee TC, Covington CD, Fuller RW, Bokesch HR, Young S, et al.
Author(s): Kawazu K, Ohigashi H, Takahashi N, Mitsui T
Author(s): Leu T, Raharivelomanana P, Soulet S, Bianchini JP, Herbette G, et al.
Author(s): Iinuma M, Tosa H, Tanaka T, Yonemori S
Author(s): Jeboury FSA, Locksley HD
Author(s): Kumar V, Ramachandran S, Sultanbawa MUS
Author(s): Li YZ, Li LZ, Hua HM, Li ZG, Liu MS
Author(s): Laure F, Herbette G, Faure R, Bianchini JP, Raharivelomanana P, et al.
Author(s): Govindachari TR, Vishwanathan N, Pai BR, Ramadas Rao U, Srinivasan M
Author(s): Patil AD, Freyer AJ, Eggleston DS, Haltiwanger RC, Bean MF, et al.
Author(s): Spino C, Marco D, Subramaniam S
Author(s): Itoigawa M, Ito C, Tan HTW, Kuchide M, Tokuda H, et al.
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