Author(s): Guadaño A, Gutiérrez C, de La Peña E, Cortes D, González-Coloma A
Annonaceous acetogenins represent a new class of bioactive compounds whose primary mode of action is the inhibition of NADH-ubiquinone oxidoreductase. Given the potential pesticidal use of such a class of compounds, we have further evaluated the antifeedant and insecticidal effects of squamocin and annonacin, two annonaceous acetogenins, on Spodoptera littoralis, Leptinotarsa decemlineata, and Myzus persicae. Additionally, to partially assess their environmental risk, we have also tested their mutagenicity in Salmonella typhimurium strains TA98, TA100, and TA102 in the presence and absence of a metabolic activation system. Among the test compounds, annonacin showed antifeedant effects on L. decemlineata, while squamocin was toxic to L. decemlineata and M. persicae. Neither acetogenin was mutagenic, although both were toxic in the absence of a metabolic activation system. We compared these results with those obtained with rotenone, a well-known respiratory inhibitor that was highly toxic to L. decemlineata and M. persicae and showed no mutagenicity/toxicity in the S. typhimurium strains tested up to a concentration of 1000 microg per plate.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/10869199
Author(s): Dos Santos AF, Sant’ana AE
Author(s): Pavela R
Author(s): Tarelli G, Zerba EN, Alzogaray RA
Author(s): Pohlit AM, Rezende AR, Lopes Baldin EL, Lopes NP, Neto VF
Author(s): Moeschler HF, Pfluger W, Wendisch D
Author(s): Mikolajczak KJ, McLaughlin JL, Rupprecht JK
Author(s): Mikolajczak KJ, McLaughlin JL, Rupprecht JK
Author(s): Teresa G, Raul A, Jose RT, Amparo MB, Carmen ZMP
Author(s): Mehra BK, Hiradhar PK
Author(s): George S, Vincent S
Author(s): González-Coloma A, Guadaño A, de Inés C, Martínez-Díaz R, Cortes D
Author(s): Coelho MB, Marangoni S, Macedo ML
Author(s): Kempraj V, Bhat KS
Author(s): Anderson JR, Poorbaugh JH
Author(s): Tan SW, Yap KL, Lee HL
Author(s): Crosskey RW, Lane RP
Author(s): Howard J
Author(s): Abbott WS
Author(s): Knecht W, Altekruse D, Rotgeri A, Gonski S, Löffler M
Author(s): Lowry OH, Rosebrough NJ, Farr AL, Randall RJ
Author(s): Singer TP
Author(s): Yang NC, Ho WM, Chen YH, Hu ML
Author(s): Zafra-Polo MC, González MC, Estornell E, Sahpaz S, Cortes D
Author(s): Byun HO, Kim HY, Lim JJ, Seo YH, Yoon G
Author(s): Greenberg B
Author(s): Kazuyoshi K, Jocelyn PA, Kobayashi A
Author(s): Richter C, Park JW, Ames BN