Author(s): Zou Z, Yi Y , Wu H, Wu J, Liaw C et al.
Three new triterpene glycosides, intercedensides A (1), B (2), and C (3), were isolated from the sea cucumber Mensamria intercedens Lampert, which is found in the South China Sea, and their structures have been elucidated by spectroscopic analysis (NMR and ESIMS) and chemical transformations. Intercedensides A (1) and C (3) have a conjugated double bond (22E,24-diene) in the side chain of the aglycon. Intercedenside B (2) has two beta-D-xylose and two sulfate groups in the carbohydrate chain. All three glycosides showed significant cytotoxicity against 10 human tumor cell lines with ED(50) in the range 0.6-4.0 microg/mL. Intercedenside A (1) exhibited significant in vivo antineoplastic activity against mouse Lewis lung cancer and mouse S180 sarcoma. On the basis of these initially promising results, intercedensides A-C merit further study as potential anticancer agents.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/12932123
Author(s): Mahato SB, Garai S
Author(s): Lacalla-Dubois M, Wagner H
Author(s): Francis G, Kerem Z, Makkar HP, Becker K
Author(s): Vincken JP, Heng L, de Groot A, Gruppen H
Author(s): Dinda B, Debnath S, Mohanta BC, Harigaya Y
Author(s): Agarwal SK, Rastogi RP
Author(s): Chandel RS, Rastogi RP
Author(s): Mahato SB, Ganguly AN, Sahu NP
Author(s): Mahato SB, Garai S, Chakravarty AK
Author(s): Chakravarty AK, Garai S, Masuda K, Nakane T, Kawahara N
Author(s): Murray AP, Muniain C, Seldes AM, Maier MS
Author(s): Welfender J, Rodriguez S, Hostettmann K
Author(s): Renukappa T, Roos G, Klaiber I, Vogler B, Kraus W
Author(s): Nyberg NT, Baumann H, Kenne L
Author(s): Williams DH, Bradley C, Bojesen G
Author(s): Lattimer RP, Schulten HR
Author(s): Sundqvist B, Roepstorff P, Fohlman J, Hedin A, Håkansson P, et al.
Author(s): Karas M, Hillenkamp F
Author(s): Broberg S, Nord LI, Kenne L
Author(s): Liu J, Yang X, He J, Xia M, Xu L, et al.
Author(s): Zehl M, Pittenauer E, Jirovetz L, Bandhari P, Singh B et al.
Author(s): Germonprez N, Puyvelde LV, Maes L, Tri MV, De Kimpe N
Author(s): Zhang H, Lu Z, Tan GT, Qiu S, Farnsworth NR et al.
Author(s): Zhang XM, Yang DP, Xie ZY, Xue X, Zhu LP, et al.
Author(s): Arslan I
Author(s): Ma L, Yu AH, Sun LL, Gao W, Zhang MM et al.
Author(s): Moniuszko-Szajwaj B, Pecio L, Kowalczyk M, Simonet AM, Macias FA, et al.
Author(s): Xi FM, Li CT, Mi JL, Wu ZJ, Chen WS
Author(s): Lacaille-Dubois MA, Wagner H
Author(s): Li XC, ElSohly HN, Nimrod AC, Clark AM
Author(s): Bills G, Dombrowski A, Morris SA, Hensens O, Liesch, JM et al.
Author(s): Chludil HD, Muniain CC, Seldes AM, Maier MS
Author(s): Huang H, Liao S, Chang F, Kuo Y, Wu Y
Author(s): Abdel-Gawad MM, El-Amin SM, Ohigashi H, Watanabe Y, Takeda N, et al.
Author(s): Jayasinghe ULB, Fujimoto Y, Hostettmann K
Author(s): Cheng G, Zhang Y, Zhang X, Tang H, Cao W et al.
Author(s): Kim YS, Kim JS, Choi SU, Kim JS, Lee HS, et al.
Author(s): Zheng L, Zheng J, Zhao Y, Wang B, Wu L, et al.
Author(s): Xiao K, Yi YH, Wang ZZ, Tang HF, Li YQ, et al.
Author(s): Kuroda M, Mimaki Y, Sashida Y, Kitahara M, Yamazaki M et al.
Author(s): Mimaki Y, Hurade H, Sakuma C, Haraguchi M, Yui S et al.
Author(s): Mimaki Y, Harada H, Sakuma C, Haraguchi M, Yui S, et al.
Author(s): Zhao M, Ma N, Qiu F, Hai WL, Tang HF, et al.
Author(s): Li X, Zhao J, Peng C, Chen Z, Liu Y, et al.
Author(s): Li Q, Deng L, Li W, Koike K
Author(s): Cheng L, Xia TS, Wang YF, Zhou W, Liang XQ, et al.
Author(s): Han L, Fang Y, Li M, Yang H, Huang F
Author(s): Yoshikawa M, Murakami T, Matsuda H, Yamahara J, Murakami N, et al.
Author(s): Yoshikawa M, Murakami T, Matsuda H, Yamahara J, Murakami N, et al.
Author(s): Sakurai T, Nishimura T, Otake N, Xinsheng Y, Abe K, et al.
Author(s): Kako M, Miura T, Nishiyama Y, Ichimaru M, Moriyasu M, et al.
Author(s): Sakurai T, Nishimura T, Otake N, Xinsheng Y, Abe K, et al.
Author(s): Hu X, Wang S, Xu J, Wang DB, Chen Y, et al.
Author(s): Koneri RB, Samaddar S, Ramaiah CT
Author(s): Sinha J, Raay B, Das N, Medda S, Garai S, et al.
Author(s): Udayama M, Ohkawa M, Yoshida N, Kinjo J, Nohara T
Author(s): Sumathy T, Subramanian S, Govindasamy S, Balakrishna K, Veluchamy G
Author(s): Matsuda H, Murakami T, Ninomiya K, Inadzuki M, Yoshikawa M
Author(s): Huang B, Fu HZ, Chen WK, Luo YH, Ma SC
Author(s): Wang Y, Zhang CL, Liu YF, Liang D, Luo H, et al.
Author(s): Pawar RS, Bhutani KK
Author(s): Li S, Zhao J, Liu Y, Chen Z, Xu Q, et al.
Author(s): Qiu M, Kim JH, Lee HK, Min BS
Author(s): Song W, Si L, Ji S, Wang H, Fang XM, et al.
Author(s): Yang XW, Zhao J, Cui YX, Liu XH, Ma CM, et al.
Author(s): Li JP, Liang ZM, Yuan Z
Author(s): Ukiya M, Akihisa T, Yasukawa K, Koike K, Takahashi A, et al.
Author(s): Choo MK, Park EK, Han MJ, Kim DH
Author(s): Bi Y, Ma C, Zhang H, Zhou Z, Yang J, et al.
Author(s): Eisenreich W, Bacher A, Arigoni D, Rohdich F
Author(s): Washida D, Shimomura K, Nakajima Y, Takido M, Kitanaka S
Author(s): Mallol A, Cusidó RM, Palazón J, Bonfill M, Morales C, et al.
Author(s): Sahu NP, Koike K, Jia Z, Achari B, Banerjee S, et al.
Author(s): Toth G, Simon A, Elganal MHA, Soliman SM, Elmunajjed DT, et al.
Author(s): Radwan MM, El-Sebakhy NA, Asaad AM, Toaima SM, Kingston DG
Author(s): Lavaud C, Crublet ML, Pouny I, Litaudon M, Sévenet T
Author(s): Perrone A, Masullo M, Bassarello C, Hamed AI, Belisario MA, et al.
Author(s): Abdel Khalik SM, Miyase T, El-Ashaal HA, Melek FR
Author(s): Tabudravu JN, Jaspars M
Author(s): Hu L, Chen Z, Xie Y
Author(s): Yin F, Hu LH
Author(s): Luo JG, Kong LW
Author(s): Koike K, Jia Z, Nikaido T
Author(s): Kanchanapoom T, Kasai R, Yamasaki K
Author(s): Kitajima M, Hashimoto K, Yokoya M, Takayama H, Sandoval M, et al.
Author(s): Jia Z, Koike K, Kudo M, Li H, Nikaido T
Author(s): Cuéllar MJ, Giner RM, Recio MC, Just MJ, Máñez S, et al.
