Author(s): Freitas CS, Baggio CH, Da Silva-Santos JE, Rieck L, de Moraes Santos CA, et al.
The plants belonging to Pfaffia genus are used in folk medicine to treat gastric disturbances. This study examined the effects of an aqueous extract of Pfaffia glomerata (Spreng) Pedersen (AEP) on the gastrointestinal tract. Wistar rats were pretreated orally (p.o.) with the AEP (125, 250, 500 and 1000 mg.kg(-1)) before induction of ulcers by hypothermic restraint stress (HRS, 3 h restraint stress at 4 degrees C), ethanol (ET, 70%; 0.5 ml/animal; p.o.) or indomethacin (IND, 20 mg.kg(-1); s.c.). Control animals received water (C) or ranitidine (60 mg.kg(-1)) p.o. The AEP protected rats against HRS and ET-induced ulcers, but was not able to protect the gastric mucosa against IND-induced ulcers. When injected into the duodenal lumen, the AEP reduced total acidity and both basal and histamine-stimulated acid secretion in pylorus-ligated rats. In addition, gastric secretion from AEP-treated animals exhibited increased concentrations of nitrite and nitrate. Treatment of animals with L-NAME (120 mg.kg(-1), p.o.) prevented both the reduction of total acidity and the increase in NOx levels promoted by AEP treatment. In conclusion, AEP effectively protected the gastric mucosa and inhibited gastric acid secretion in rats, probably by involving the histaminergic pathway and an enhanced production of nitric oxide in the stomach.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/14687657
Author(s): Wang P, Li S, Ownby S, Zhang Z, Yuan W, et al.
Author(s): Salvador MJ, Ferreira EO, Mertens-Talcott SU, De Castro WV, Butterweck V, et al.
Author(s): Cai Y, Sun M, Corke H
Author(s): Li H, Deng Z, Liu R, Zhu H, Draves J, et al.
Author(s): Liu H, Cao J, Jiang W
Author(s): Souza JG, Tomei RR, Kanashiro A, Kabeya LM, Azzolini AECS, et al.
Author(s): Kumar G, Karthik L, Rao KV
Author(s): Ranju P, Kundlik G, Hitesh G, Thirumoorthy N
Author(s): Biella CA, Salvador MJ, Dias DA, Dias-Baruffi M, Crotti LSP
Author(s): Teixeira CGL, Piccoli A, Costa P, Soares L, Da Silva-Santos JE
Author(s): Sanoko R, Esperanza G, Pizza C, De Tommasi N
Author(s): Harbone JB
Author(s): Piccinelli AL, De Simone F, Passi S, Rastrelli L
Author(s): Cuendet M, Hostettman K, Potterat O, Dyatmko W
Author(s): Huang D, Ou B, Prior RL
Author(s): Ou B, Hampsch-Woodill M, Prior RL
Author(s): Salvador MJ, de Lourenço CC, Andreazza NL, Pascoal AC, Stefanello ME
Author(s): Ye M, Han J, Chen H, Zheng J, Guo D
Author(s): Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, et al.
Author(s): Pietta PG
Author(s): Rice-Evans CA, Miller NJ, Paganga G
Author(s): Soares SE
Author(s): Zocoler AMD, Sanches ACC, Albrecht I, Mello JCP
Author(s): Custodio L, Fernandes E, Escapa AL, Fajardo A, Aligue R, et al.
Author(s): Salvador MJ, Andreazza NL, Pascoal ACRF, Pereira PS, França SC, et al.
Author(s): Carneiro CS, Costa-Pinto FA, da Silva AP, Pinello KC, da Silva TC, et al.
Author(s): Rao YK, Geethangili M, Fang SH, Tzeng YM
Author(s): Choi HJ, Eun JS, Kim BG, Kim SY, Jeon H, et al.
Author(s): Zhou Y, Liu YE, Cao J, Zeng G, Shen C, et al.