Isolation of antibacterial fatty acids from Schotiabrachypetala

Author(s): McGraw LJ, Jager AK, Van Staden J

Abstract

In southern Africa, the roots of Schotia brachypetala are used by traditional healers to treat dysentery and diarrhoea. Activity-directed fractionation of the ethanol extract of the dried leaves yielded 9,12,15-octadecatrienoic (linolenic) acid and methyl-5,11,14,17-eicosatetraenoate. These fatty acids displayed antibacterial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus and to a lesser extent, against the Gram-negative Escherichia coli and Klebsiella pneumoniae.

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