Author(s): Simmons TL, Andrianasolo E, McPhail K, Flatt P, Gerwick WH
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/15713904
Author(s): Haefner B
Author(s): Belarbi el H, Contreras Gómez A, Chisti Y, García Camacho F, Molina Grima E
Author(s): Sipkema D, Franssen MC, Osinga R, Tramper J, Wijffels RH
Author(s): Alcaraz MJ, Payá M
Author(s): Paul VJ
Author(s): Green G
Author(s): Proksch P
Author(s): Taylor MW, Radax R, Steger D, Wagner M
Author(s): Stowe SD, Richards JJ, Tucker AT, Thompson R, Melander C, et al.
Author(s): Thompson JE, Walker RP, Faulkner DJ
Author(s): Beccero MA, Turon X, Uriz MJ
Author(s): Becerro MA, Thacker RW, Turon X, Uriz MJ, Paul VJ
Author(s): Muller WEG
Author(s): Lavrov D
Author(s): By Phil Myers
Author(s): Molinski TF, Dalisay DS, Lievens SL, Saludes JP
Author(s): Gordaliza M
Author(s): Hallock YF, Cragg GM
Author(s): Hildebrand M, Waggoner LE, Lim GE, Sharp KH, Ridley CP, et al.
Author(s): Baker DD, Chu M, Oza U, Rajgarhia V
Author(s): Newman DJ, Cragg GM
Author(s): Newman DJ, Cragg GM
Author(s): Sagar S, Kaur M, Minneman KP
Author(s): Villa FA, Gerwick L
Author(s): Frota MJ, Silva RB, Mothes B, Henriques AT, Moreira JC
Author(s): Blunt JW, Copp BR, Keyzers RA, Munro MH, Prinsep MR
Author(s): Shaaban M, Abd-Alla HI, Hassan AZ, Aly HF, Ghani MA
Author(s): Longeon A, Copp BR, Quévrain E, Roué M, Kientz B, et al.
Author(s): Utkina NK
Author(s): Li Z
Author(s): Sugiyama Y, Ito Y, Suzuki M, Hirota A
Author(s): Kim SK, Dewapriya P
Author(s): Berrué F, McCulloch MW, Boland P, Hart S, Harper MK, et al.
Author(s): Abraham I, El Sayed K, Chen ZS, Guo H
Author(s): Mayer AM, Glaser KB, Cuevas C, Jacobs RS, Kem W, et al.
Author(s): Crews P, Gewick WH, Schmitz FJ, France D, Bair KW, et al.
Author(s): Wang YQ, Miao ZH
Author(s): Bergmann W, Feeney RJ
Author(s): Proksch P, Edrada RA, Ebel R
Author(s): Schwartsmann G
Author(s): Feldman EJ, Lancet JE, Kolitz JE, Ritchie EK, Roboz GJ, et al.
Author(s): Essack M, Bajic VB, Archer JA
Author(s): Sipkema D, Osinga R, Schatton W, Mendola D, Tramper J, et al.
Author(s): Newman DJ, Cragg GM
Author(s): Halim H, Chunhacha P, Suwanborirux K, Chanvorachote P
Author(s): Guzii AG, Makarieva TN, Denisenko VA, Dmitrenok PS, Kuzmich AS, et al.
Author(s): Kondracki ML, Guyot M
Author(s): Kong D, Yamori T, Kobayashi M, Duan H
Author(s): Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E
Author(s): Rothmeier AS, Schneiders UM, Wiedmann RM, Ischenko I, Bruns CJ, et al.
Author(s): Valeriote FA, Tenney K, Media J, Pietraszkiewicz H, Edelstein M, et al.
Author(s): Rabelo L, Monteiro N, Serquiz R, Santos P, Oliveira R, et al.
Author(s): Schumacher M, Cerella C, Eifes S, Chateauvieux S, Morceau F, et al.
Author(s): Shin BA, Kim YR, Lee IS, Sung CK, Hong J, et al.
Author(s): Zhao Q, Mansoor TA, Hong J, Lee CO, Im KS, et al.
Author(s): Gunasekera SP, Cranick S, Longley RE
