Author(s): Lopez D, Martinez-Luis S
P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.
Referred From: http://www.mdpi.com/1660-3397/12/1/525/htm
Author(s): Srivalli KMR, Lakshmi PK
Author(s): Abdallah HM, Al-Abd AM, El-Dine RS, El-Halawany AM