Microbial hydroxylation of natural drimenic lactones

Author(s): Maurs M, Azerad R,Corte M, Aranda G, Bertranne M, et al.

Abstract

Incubation of confertifolin and isodrimenin with Mucor plumbeus, Aspergillus niger or Rhizopus arrhizus gave in good yields the corresponding 3 beta-hydroxy derivatives. From isodrimenin, the known natural 7 alpha-hydroxy derivative (futronolide) was also obtained and its structure was definitely established by X-ray crystallographic study of its acetate derivative.

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