Author(s): Ferreira SBS, Assis Dias BR, Obregón CS, Gomes CC, de Araujo Pereira RR et al.
Ethylcellulose microparticles containing metronidazole and propolis extractive solution were prepared and evaluated in vitro against periodontal pathogens. Scanning electron microscopy, particle size analysis, drug entrapment efficiency and drug release of microparticles were determined. The antimicrobial activity of microparticles was evaluated against microorganisms of periodontal importance (Enterococcus faecalis, Streptococcus pyogenes, Streptococcus mutans, Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli). It was obtained particles with regular morphology, mean diameter of 1.23 µm, and entrapment efficiency for propolis and metronidazole were 91.41% and 22.23%, respectively. In vitro release studies of propolis and metronidazole from microparticles showed prolonged drug release and controlled by Fickian diffusion. Both propolis and metronidazole displayed activity against the tested strains. Moreover, the results showed that the strains of E. faecalis, S. pyogenes and S. mutans were more susceptible to the propolis and E. faecalis to the metronidazole. It was also observed that the amount of metronidazole to inhibit the microorganism strains in the physical mixture with propolis was smaller than in the metronidazole alone, suggesting potentiation effect between propolis and metronidazole. These microparticles would be useful for developing intermediary or eventual dosage form to be administered into the periodontal pocket more easily and safely.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/23356908
Author(s): Ramalingam K, Amaechi BT, Ralph RH, Lee VA
Author(s): Fukushima T, Iwao H, Nakazima A, Miki M, Sakai T, et al.
Author(s): Rokadiya S, Malden NJ
Author(s): Dessì A, Crisafulli M, Accossu S, Setzu V, Fanos V
Author(s): Santos FA, Bastos EM, Rodrigues PH, Uzeda M, Carvalho MAR, et al.
Author(s): Sreeja S, Babu PRS, Prathab AG
Author(s): Rams TE, Degener JE, van Winkelhoff AJ
Author(s): Cragg GM, Newman DJ, Snader KM
Author(s): Maekawa LE, Valera MC, Oliveira LD, Carvalho CA, Camargo CH, et al.
Author(s): Bonifácio BV, Silva PB, Ramos MA, Negri KM, Bauab TM, et al.
Author(s): Santos VR, Gomes RT, de Mesquita RA, de Moura MD, França EC, et al.
Author(s): Pereira EM, da Silva JL, Silva FF, De Luca MP, Ferreira EF, et al.
Author(s): Gomaa OM, Gaweesh AS
Author(s): Banskota AH, Tezuka Y, Kadota S
Author(s): Dornelas CA, Fechine-Jamacaru FV, Albuquerque IL, Magalhães HI, Dias TA, et al.
Author(s): Machado JL, Assunção AK, da Silva MC, Dos Reis AS, Costa GC, et al.
Author(s): de Oliveira PF, Leandro LF, Montanheiro G, Bastos JK, da Silva Filho AA, et al.
Author(s): Oliveira GA, Ferraz ER, Souza AO, Lourenço RA, Oliveira DP, et al.
Author(s): Righi AA, Alves TR, Negri G, Marques LM, Breyer H, et al.
Author(s): Teixeira EW, Negri G, Meira RM, Message D, Salatino A
Author(s): de Almeida EB, Cordeiro Cardoso J, Karla de Lima A, de Oliveira NL, de Pontes-Filho NT, et al.
Author(s): Sharaf S, Higazy A, Hebeish A
Author(s): Santos VR
Author(s): Park YK, Alencar SM, Aguiar CL
Author(s): Batista LL, Campesatto EA, Assis ML, Barbosa AP, Grillo LA, et al.
Author(s): Marcucci MC
Author(s): Gazzani G, Daglia M, Papetti A
Author(s): Santos VR, Pimenta FJ, Aguiar MC, do Carmo MA, Naves MD, et al.
Author(s): Samet N, Laurent C, Susarla SM, Samet-Rubinsteen N
Author(s): Jebahi S, Oudadesse H, Jardak N, Khayat I, Keskes H, et al.
Author(s): Rivadeneira J, Carina Audisio M, Boccaccini AR, Gorustovich AA
Author(s): Wei QW, Dong YM, Chen XF, Li YL, Miao GH
Author(s): Kaczmarek M, Jurczyk MU, Rubis B, Banaszak A, Kolecka A, et al.
Author(s): Andrade AL, Manzi D, Domingues RZ
Author(s): Alencar SM, Oldoni TL, Castro ML, Cabral IS, Costa-Neto CM, et al.
Author(s): Daugsch A, Moraes CS, Fort P, Park YK
Author(s): Trusheva B, Popova M, Bankova V, Simova S, Marcucci MC, et al.
Author(s): Miorin PL, Levy Junior NC, Custodio AR
Author(s): Ayres DC, Marcucci MC, Giorgio S
Author(s): Park YK, Koo MH, Abreu JA, Ikegaki M, Cury JA, et al.
Author(s): Leitão DP, Filho AA, Polizello AC, Bastos JK, Spadaro AC
Author(s): Topcuoglu N, Ozan F, Ozyurt M, Kulekci G
Author(s): Ramos DBM, Gomes FS, Napoleão TH, Paiva PMG, Silva MDC, et al.
Author(s): Bueno-Silva B, Alencar SM, Koo H, Ikegaki M, Silva GV, et al.
Author(s): Libério SA, Pereira AL, Araújo MJ, Dutra RP, Nascimento FR, et al.
Author(s): Dziedzic A, Kubina R, Wojtyczka RD, KabaÅ‚a-Dzik A, Tanasiewicz M, et al.
Author(s): Jorgensen JH, Swenson JM, Tenover FC, Barry A, Ferraro MJ, et al.
Author(s): Gajan EB, Shirmohammadi A, Aghazadeh M, et al.
Author(s): Pondei K, Fente BG, Oladapo O
Author(s): Song XL, Sun YY, Liu Y, Chen Q, Bi XX, et al.
Author(s): Poptani B, Sharaff M, Archana G, Parekh V
Author(s): Cao WB, Su D, Chen YM, Zheng YZ, Zhang FK, et al.
Author(s): Olczak-Kowalczyk D, Daszkiewicz M, Krasuska-Slawinska, Dembowska-Baginska B, Gozdowski D, et al.
Author(s): Allan I, Newman H, Wilson M
Author(s): Krishnan V, Lakshmi T