Author(s): Crews P, Gewick WH, Schmitz FJ, France D, Bair KW, et al.
This paper outlines the results of a collaborative program begun in 1990 under the NIH National Cooperative Drug Discovery Group (NCDDG) program. It involves the unified research of a multi-institutional group from both academic and corporate laboratories. Our working hypothesis is that targets identified through basic molecular and cell biology studies are relevant for the treatment of human cancers. Thus, a broad range of primary biochemical assays have guided the examination of extracts obtained from marine organisms (both collected and cultured) and purified marine natural products. The goal is to discover small molecules effective against these biological targets. An ever-changing panel of assays focus on a number of cancer relevant targets associated with the cell cycle, signal transduction, angiogenesis or apoptosis. A massive library of materials has been assembled for evaluation in the screens and it consists of more than 900 compounds and 16,000 extracts. We believe that these samples have enormous potential for chemodiveristy and progress to date supports this contention. The first part of the paper focuses on highlights from the period 1995–1999. The two most important developments were that the bengamide and the psammaplin families provided important insights leading to the development of two compounds, LAF-389 and NVP-LAQ824. These were both advanced to Phase I anti-cancer clinical trials. A sampling of recent discoveries, including current leads in development is also discussed. Attention then turns to new technologies and strategies aimed at shortening the time interval from an initial lead candidate discovery to assessment of its future therapeutic potential.
Author(s): Haefner B
Author(s): Belarbi el H, Contreras Gómez A, Chisti Y, García Camacho F, Molina Grima E
Author(s): Sipkema D, Franssen MC, Osinga R, Tramper J, Wijffels RH
Author(s): Alcaraz MJ, Payá M
Author(s): Paul VJ
Author(s): Green G
Author(s): Proksch P
Author(s): Taylor MW, Radax R, Steger D, Wagner M
Author(s): Stowe SD, Richards JJ, Tucker AT, Thompson R, Melander C, et al.
Author(s): Thompson JE, Walker RP, Faulkner DJ
Author(s): Beccero MA, Turon X, Uriz MJ
Author(s): Becerro MA, Thacker RW, Turon X, Uriz MJ, Paul VJ
Author(s): Muller WEG
Author(s): Lavrov D
Author(s): By Phil Myers
Author(s): Molinski TF, Dalisay DS, Lievens SL, Saludes JP
Author(s): Simmons TL, Andrianasolo E, McPhail K, Flatt P, Gerwick WH
Author(s): Gordaliza M
Author(s): Hallock YF, Cragg GM
Author(s): Hildebrand M, Waggoner LE, Lim GE, Sharp KH, Ridley CP, et al.
Author(s): Baker DD, Chu M, Oza U, Rajgarhia V
Author(s): Newman DJ, Cragg GM
Author(s): Newman DJ, Cragg GM
Author(s): Sagar S, Kaur M, Minneman KP
Author(s): Villa FA, Gerwick L
Author(s): Frota MJ, Silva RB, Mothes B, Henriques AT, Moreira JC
Author(s): Blunt JW, Copp BR, Keyzers RA, Munro MH, Prinsep MR
Author(s): Shaaban M, Abd-Alla HI, Hassan AZ, Aly HF, Ghani MA
Author(s): Longeon A, Copp BR, Quévrain E, Roué M, Kientz B, et al.
Author(s): Utkina NK
Author(s): Li Z
Author(s): Sugiyama Y, Ito Y, Suzuki M, Hirota A
Author(s): Kim SK, Dewapriya P
Author(s): Berrué F, McCulloch MW, Boland P, Hart S, Harper MK, et al.
Author(s): Abraham I, El Sayed K, Chen ZS, Guo H
Author(s): Mayer AM, Glaser KB, Cuevas C, Jacobs RS, Kem W, et al.
Author(s): Wang YQ, Miao ZH
Author(s): Bergmann W, Feeney RJ
Author(s): Proksch P, Edrada RA, Ebel R
Author(s): Schwartsmann G
Author(s): Feldman EJ, Lancet JE, Kolitz JE, Ritchie EK, Roboz GJ, et al.
Author(s): Essack M, Bajic VB, Archer JA
Author(s): Sipkema D, Osinga R, Schatton W, Mendola D, Tramper J, et al.
Author(s): Newman DJ, Cragg GM
Author(s): Halim H, Chunhacha P, Suwanborirux K, Chanvorachote P
Author(s): Guzii AG, Makarieva TN, Denisenko VA, Dmitrenok PS, Kuzmich AS, et al.
Author(s): Kondracki ML, Guyot M
Author(s): Kong D, Yamori T, Kobayashi M, Duan H
Author(s): Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E
Author(s): Rothmeier AS, Schneiders UM, Wiedmann RM, Ischenko I, Bruns CJ, et al.
Author(s): Valeriote FA, Tenney K, Media J, Pietraszkiewicz H, Edelstein M, et al.
Author(s): Rabelo L, Monteiro N, Serquiz R, Santos P, Oliveira R, et al.
Author(s): Schumacher M, Cerella C, Eifes S, Chateauvieux S, Morceau F, et al.
Author(s): Shin BA, Kim YR, Lee IS, Sung CK, Hong J, et al.
Author(s): Zhao Q, Mansoor TA, Hong J, Lee CO, Im KS, et al.
Author(s): Gunasekera SP, Cranick S, Longley RE