Molecular mechanisms for the anti-cancer effects of diallyl disulfide

Yi L; Su Q

Molecular mechanisms for the anti-cancer effects of diallyl disulfide

Author(s): Yi L, Su Q

Abstract

Considerable evidence in recent years suggests that garlic has anti-proliferative effects against various types of cancer. Garlic contains water-soluble and oil-soluble sulfur compounds. Oil-soluble compounds such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS) and ajoene are more effective than water-soluble compounds in protection against cancer. DADS, a major organosulfur compound derived from garlic, can decrease carcinogen-induced cancers in experimental animals and inhibit the proliferation of various types of cancer cells. Its mechanisms of action include: the activation of metabolizing enzymes that detoxify carcinogens; suppression of the formation of DNA adducts; antioxidant effects; regulation of cell-cycle arrest; induction of apoptosis and differentiation; histone modification; and inhibition of angiogenesis and invasion. These topics are discussed in depth in this review.

Referred From: https://www.ncbi.nlm.nih.gov/pubmed/23583486

Natural Products Chemistry & Research
has published an article entitled(Impact of Quercetin, Diallyl Disulfide and Nimbolide on the Regulation of Nuclear Factor Kappa B Expression in Prostate and Breast Cancer Cell Lines) & referenced following source

Molecular mechanisms for the anti-cancer effects of diallyl disulfide

Abstract

Similar Articles

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis

Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation

Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway

N-tosyl-L-phenylalanine chloromethyl ketone inhibits NF-kappaB activation by blocking specific cysteine residues of IkappaB kinase beta and p65/RelA

Signaling by distinct classes of phosphoinositide 3-kinases

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB

Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin

Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells

Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions

Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells

Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells

Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5

Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3)

Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)

Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax

Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-kB in colon cancer cells

Nimbolide, a neem limonoid abrogates canonical NF-kB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

Protein measurement with the Folin phenol reagent

Garlic compound, diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3

Effects of diallyl disulfide (DADS) on expression of apoptosis associated proteins in androgen independent human prostate cancer cells (PC-3)