Author(s): Lynch JW
The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem and retina. They are also found presynaptically, where they modulate neurotransmitter release. Functional GlyRs are formed from a total of five subunits (alpha1-alpha4, beta). Although alpha subunits efficiently form homomeric GlyRs in recombinant expression systems, homomeric alpha1, alpha3 and alpha4 GlyRs are weakly expressed in adult neurons. In contrast, alpha2 homomeric GlyRs are abundantly expressed in embryonic neurons, although their numbers decline sharply by adulthood. Numerous lines of biochemical, biophysical, pharmacological and genetic evidence suggest the majority of glycinergic neurotransmission in adults is mediated by heteromeric alpha1beta GlyRs. Immunocytochemical co-localisation experiments suggest the presence of alpha2beta, alpha3beta and alpha4beta GlyRs at synapses in the adult mouse retina. Immunocytochemical and electrophysiological evidence also implicates alpha3beta GlyRs as important mediators of glycinergic inhibitory neurotransmission in nociceptive sensory neuronal circuits in peripheral laminae of the spinal cord dorsal horn. It is yet to be determined why multiple GlyR synaptic subtypes are differentially distributed in these and possibly other locations. The development of pharmacological agents that can discriminate strongly between different beta subunit-containing GlyR isoforms will help to address this issue, and thereby provide important insights into a variety of central nervous system functions including retinal signal processing and spinal pain mechanisms. Finally, agents that selectively potentiate different GlyR isoforms may be useful as therapeutic lead compounds for peripheral inflammatory pain and movement disorders such as spasticity.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/18721822
Author(s): Rates SM
Author(s): Stevenson DE, Hurst RD
Author(s): Kandaswami C, Middleton E Jr
Author(s): Kandaswami C, Perkins E, Drzewiecki G, Soloniuk DS, Middleton E Jr
Author(s): Middleton E Jr, Kandaswami C, Theoharides TC
Author(s): Ibraheim ZZ, Abdel-Mageed WM, Dai H, Guo H, Zhang L, et al.
Author(s): Macho A, Blanco-Molina M, Spagliardi P, Appendino G, Bremner P, et al.
Author(s): Colman-Saizarbitoria T, Boutros P, Amesty A, Bahsas A, Mathison Y, et al.
Author(s): Zamaraeva M, Charishnikova O, Saidkhodjaev A, Isidorov V, Granosik M, et al.
Author(s): Abourashed EA, Galal AM, El-Feraly FS, Khan IA
Author(s): Hosseinzadeh H, Parvardeh S
Author(s): Abdel-Fattah AM, Matsumoto K, Watanabe H
Author(s): Houghton PJ, Zarka R, de las Heras B, Hoult JR
Author(s): Worthen DR, Ghosheh OA, Crooks PA
Author(s): Wie MB, Won MH, Lee KH, Shin JH, Lee JC, et al.
Author(s): Irie Y, Itokazu N, Anjiki N, Ishige A, Watanabe K, et al.
Author(s): Surh YJ, Park KK, Chun KS, Lee LJ, Lee E, et al.
Author(s): Ali BH, Blunden G, Tanira MO, Nemmar A
Author(s): Raafat K, Breitinger U, Mahran L, Ayoub N, Breitinger HG
Author(s): Raafat KM, Jassar H, Aboul-Ela M, El-Lakany A
Author(s): Betz H, Kuhse J, Fischer M, Schmieden V, Laube B, et al.
Author(s): Breitinger HG, Becker CM
Author(s): Legendre P
Author(s): Lynch JW
Author(s): Becker L, von Wegerer J, Schenkel J, Zeilhofer HU, Swandulla D, et al.
Author(s): Chindo BA, Anuka JA, McNeil L, Yaro AH, Adamu SS, et al.
Author(s): Lambert DM, Poupaert JH, Maloteaux JM, Dumont P
Author(s): Bloomenthal AB, Goldwater E, Pritchett DB, Harrison NL