Author(s): Babykutty S, S PP, J NR, Kumar MA, Nair MS, et al.
Nimbolide, a plant-derived limonoid has been shown to exert its antiproliferative effects in various cell lines. We demonstrate that nimbolide effectively inhibited proliferation of WiDr colon cancer cells through inhibition of cyclin A leading to S phase arrest. It also caused activation of caspase-mediated apoptosis through the inhibition of ERK1/2 and activation of p38 and JNK1/2. Further nimbolide effectively retarded tumor cell migration and invasion through inhibition of metalloproteinase-2/9 (MMP-2/9) expression, both at the mRNA and protein level. It was also a strong inhibitor of VEGF expression, promoter activity, and in vitro angiogenesis. Finally, nimbolide suppressed the nuclear translocation of p65/p50 and DNA binding of NF-κB, which is an important transcription factor for controlling MMP-2/9 and VEGF gene expression.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/21678498
Author(s): Ting AT, Pimentel-Muinos FX, Seed B
Author(s): Reynaert NL, Ckless K, Korn SH, Vos N, Guala AS, et al.
Author(s): Pandey MK, Sung B, Ahn KS, Kunnumakkara AB, Chaturvedi MM, et al.
Author(s): Ha KH, Byun MS, Choi J, Jeong J, Lee KJ, et al.
Author(s): Vanhaesebroeck B, Waterfield MD
Author(s): Vivanco I, Sawyers CL
Author(s): Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, et al.
Author(s): Kandel ES, Hay N
Author(s): Choi JA, Kim JY, Lee JY, Kang CM, Kwon HJ, et al.
Author(s): Kuo PC, Liu HF, Chao JI
Author(s): Ong CS, Tran E, Nguyen TT, Ong CK, Lee SK, et al.
Author(s): Vijayababu MR, Arunkumar A, Kanagaraj P, Arunakaran J
Author(s): Choi EJ, Bae SM, Ahn WS
Author(s): Jung YH, Heo J, Lee YJ, Kwon TK, Kim YH
Author(s): Senthilkumar K, Elumalai P, Arunkumar R, Banudevi S, Gunadharini ND, et al.
Author(s): Senthilkumar K, Arunkumar R, Elumalai P, Sharmila G, Gunadharini DN, et al.
Author(s): Yi L, Su Q
Author(s): Gupta SC, Reuter S, Phromnoi K, Park B, Hema PS, et al.
Author(s): Kavitha K, Vidya Priyadarsini R, Anitha P, Ramalingam K, Sakthivel R, et al.
Author(s): Lowry OH, Rosebrough NJ, Farr AL, Randall RJ
Author(s): Arunkumar A, Vijayababu MR, Srinivasan N, Aruldhas MM, Arunakaran J
Author(s): Gayathri R, Gunadharini DN, Arunkumar A, Senthilkumar K, Krishnamoorthy G, et al.