Author(s): Wang GYS, Graziani E, Waters B, Pan W, Li X, McDermott J,et al.
As a route to accessing the potential chemical diversity of uncultivable microbes from the soil, combinatorial biosynthetic libraries were constructed by cloning large fragments of DNA isolated from soil into a Streptomyces lividans host. Four novel compounds, terragines A (1), B (2), C (3), and D (4), were isolated from recombinant 436-s4-5b1, and another novel compound, terragine E (5), was isolated from 446-s3-102g1. The structures were determined by a combination of spectroscopic techniques, primarily 2D NMR.
Referred From: http://pubs.acs.org/doi/abs/10.1021/ol005860z
Author(s): Caceres A, Cebera Morale O, Mollideo P, Mendia P
Author(s): John MW, Maria GB