Author(s): Arteel GE
Although there are numerous experimental data indicating that oxidative stress plays a role in the initiation and progression of alcohol-induced liver disease (ALD), this work has yet to translate into an accepted antioxidant therapy for ALD in humans. With a better understanding of the mechanisms by which oxidative stress leads to liver damage during alcohol exposure, therapies that are more targeted at the cellular/molecular level may be applied in the clinic with potentially greater success. This article discusses the general concepts of oxidative stress and how it relates to current hypotheses in alcohol-induced liver injury, as well as lists several key questions that remain to be addressed in this field: (1) Which prooxidants are involved in ALD? (2) What are the sources of prooxidants in the liver during alcohol exposure? (3) How are oxidants involved in alcohol-induced liver injury? (4) Can a rational and effective antioxidant therapy against ALD be developed?
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/12612915
Author(s): Halliwell B
Author(s): Rackova L, Oblozinsky M, Kostalova D, Kettmann V, Bezakova L
Author(s): Kinnula VL, Crapo JD
Author(s): Singh U, Jialal I
Author(s): Sas K, Robotka H, Toldi J, Vecsei L
Author(s): Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G
Author(s): Guidi I, Galimberti D, Lonati S, Novembrino C, Bamonti F, et al.
Author(s): Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ
Author(s): Ramakrishna BS, Varghese R, Jayakumar S, Mathan M, Balasubramanian KA
Author(s): Hyun DH, Hernandez JO, Mattson MP, de Cabo R
Author(s): Upston JM, Kritharides L, Stocker R
Author(s): Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M
Author(s): Atawodi SE, Atawodi JC, Pfundstein B, Spiegelhalder B, Bartsch H, et al.
Author(s): Atawodi SE, Atawodi JC, Idakwo GA, Pfundstein B, Haubner R, et al
Author(s): Dike IP, Obembe OO, Adebiyi FE
