Palladium-catalyzed asymmetric hydrogenation of fluorinated quinazolinones

Author(s): Duan Y, Zhu XY, Ma JA, Zhou YG

Abstract

A series of fluorinated quinazolinones were hydrogenated using the chiral Pd/bisphosphine complex as the catalyst, giving the corresponding fluorinated dihydroquinazolinones with up to 98% enantioselectivity.

Graphical abstract

A series of fluorinated quinazolinones were hydrogenated using the chiral Pd/bisphosphine complex as the catalyst, giving the corresponding fluorinated dihydroquinazolinones with up to 98% enantioselectivity.

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