Author(s): Aggarwal BB, Harikumar KB
Although safe in most cases, ancient treatments are ignored because neither their active component nor their molecular targets are well defined. This is not the case, however, with curcumin, a yellow-pigment substance and component of turmeric (Curcuma longa), which was identified more than a century ago. For centuries it has been known that turmeric exhibits anti-inflammatory activity, but extensive research performed within the past two decades has shown that this activity of turmeric is due to curcumin (diferuloylmethane). This agent has been shown to regulate numerous transcription factors, cytokines, protein kinases, adhesion molecules, redox status and enzymes that have been linked to inflammation. The process of inflammation has been shown to play a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. In the current review, we provide evidence for the potential role of curcumin in the prevention and treatment of various proinflammatory chronic diseases. These features, combined with the pharmacological safety and negligible cost, render curcumin an attractive agent to explore further.
Author(s): Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, et al.
Author(s): Syu WJ, Shen C, Don MJ, Ou JC, Lee GH, et al.
Author(s): Ahsan H, Parveen N, Khan NU, Hadi SM
Author(s): Ramsewak RS, DeWitt DL, Nair MG
Author(s): Chandran B, Goel A
Author(s): Lin JK, Pan MH, Lin-Shiau SY
Author(s): Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, et al.
Author(s): Wang D, Hu J, Lv L, Xia X, Liu J, et al.
Author(s): Pfeiffera E, Höhlea S, Solyomb AM, Metzlera M
Author(s): Shen L, Ji HF
Author(s): Cheng J, Weijun K, Yun L, Jiabo W, Haitao W, et al.
Author(s): Long Y, Zhang W, Wang F, Chen Z
Author(s): Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK
Author(s): Syed HK, Liew KB, Loh KO, Peh KK
Author(s): Wichitnithad W, Jongaroonngamsang N, Pummangura S, Rojsitthisak P
Author(s): Jadhav BK, Mahadik KR, Paradkar AR
Author(s): Shervington LA, Abba M, Hussain B, Donnelly J