Pregnane glycosides from Leptadenia pyrotechnica

Author(s): Cioffi G, Sanogo R, Vassallo A, Dal Piaz F, Autore G, et al.


The whole plant of Leptadenia pyrotechnica afforded 18 new pregnane glycosides (1-18) with sarcostin, 11-hydroxysarcostin, and deacetylmetaplexigenin as the aglycon moieties and acetyl, benzoyl, cinnamoyl, p-coumaroyl, and nicotinoyl ester moieties linked at C-12 and/or C-20 of the aglycon and hexopyranose, 6-deoxy-3-O-methylhexopyranose, and 2,6-dideoxy-3-O-methylhexopyranose sugars linked at C-3 of their aglycon. The structures of these compounds were elucidated by spectroscopic data interpretation and from chemical evidence. The antiproliferative activity of all compounds was evaluated using three continuous murine and human culture cell lines, J774.A1, HEK-293, and WEHI-164. Compounds having deacethylmetaplexigenin as aglycon and a cinnamoyl ester moiety linked at C-12 were the most active constituents.

Similar Articles

Colorectal cancer screening - methodology

Author(s): Jenkinson F, Steele RJ

Leptadenia pyrotechnica (Forssk

Author(s): El Ghonemy AA

Antioxidant, anti-lipoxygenase and cytotoxic activity of Leptadenia pyrotechnica (Forssk

Author(s): Khasawneh MA, Elwy HM, Hamza AA, Fawzi NM, Hassan AH

The p53 network: p53 and its downstream genes

Author(s): Shu KX, Li B, Wu LX

The role of the Bcl-2 protein family in cancer

Author(s): Coultas L, Strasser A

Diterpenes from the leaves of Croton zambesicus

Author(s): Block S, Baccelli C, Tinant B, Van Meervelt L, Rozenberg R, et al.

Biological effects of conjugated linoleic acids in health and disease

Author(s): Bhattacharya A, Banu J, Rahman M, Causey J, Fernandes G